Bufotenine is found in urine of all people it is not only produced in the CNS but in the periphery as well. It's levels in the cerebral spinal fluid, urine and other tissues have not been found to vary that much between patients.

There are many reasons why people would have different effects to bufotenine. The receptors are only a part of the story, BBB permeability, absorption, distribution, metabolism....

69ron SWIY seems to be hypersensitive to visual and hallucinogenic effects from what SWIM has read your reports from a variety of substances. Endogenous MAO levels have been found to vary significantly among people and this could likely be the difference rather than the endogenous levels of endogenous hallucinogens which have not been found to significantly vary b/w subjects in most studies. Although there are many many possibilities however it is likely a pharmacokinetic difference although pharmacodynamic (receptor subtypes, levels of receptor expression) may also be involved.