I do ayahuasca once every weekend. Lately, THH has been part of that.

Did a test with 300 milligrams of THH and went nowhere. For me, THH is not a MAOI.

Did just THH at 500 milligrams. For me, it seems a good SSRI but in complete darkness I get a bit of vertigo.

Have added 50 to 500 milligrams to my regular ayahuasca. At 90, it is a good improvement.

rild,

Just to confirm, 500mg THH mixed in with pharma/ayahuasca would likely cause serotonin syndrome symptoms since it has SSRI qualities at this level.

If this is true, it would probably be around 250mg for me which would be right in line with what I consumed in the jungle.

I find it so frustratingly ironic that our hosts were so adamant about making sure we understood the dangers of mixing SSRIs with ayahuasca but yet know little or nothing about drugs. "Ayahuasca is not a drug, it's medicine." Yet, every time they administer ayahuasca, it naturally is accompanied with THH which is an SSRI.

harmine and harmaline are also SSRIs. That is the point.

Do you have some figures (EC50 or similar) and references for this?

This 'paper', despite the title, informs us of nothing of the sort. There was no research done by the author.

Sorry about my last post.

I have seen harmine and harmaline described as weak SSRIs but now find text saying they are and in other places are not SSRIs. Wikipedia did describe them as weak SSRIs but removed that text.

When I take them alone, they feel like SSRI to me but slightly different than THH.

Also THH is described here and in other places as a MAOI but it does not work as one for me.

Anyone have a good source of info on this?

I suspect that this information might not exist. I've done a pretty thorough search and can't find anything. I hope I'm wrong because this is important information, especially to those of us with high sensitivity to SSRIs. It makes me wonder if the girl who died recently at an Ayahuasca retreat had a high sensitivity to SSRIs as well and had a huge dose of THH in her brew. I swear, Ayahuasca made me feel like I had a 110F fever radiating off my spine.

As to your temp of 110...

For me, aya works better if I drink the beta carbolines, wait 20 minutes and then drink the rest. A few minutes after I drink the rest, my skin temperature goes up a lot.

Where did you get this ideas from? Can you back this up a little please? Links please.

With pharmahuasca (DMT+harmine) I noticed a slight increase in body/skin temperature but with ayahuasca, it was a massive fever like heat. The problem with this ayahuasca is that I have no idea how much of what drugs (DMT+harmine+THH+harmaline) I consumed. All I know for sure is that it was made with caapi and chacruna.

Of course, I can't rule out that much of my misery from ayahuasca stems from placing DMT in my digestive tract. When I took pharmahuasca, I followed the same 20 minute separation between harmine and DMT. All of the negative symptoms seemed to pop up about 10 minutes after consuming DMT right along side the visuals and things getting strange.