I have never concidered vaping tobacco..one day when I get a vaporizer and some tobacco I will have to try it.

Growing in the rainforest it contains up to twenty times more nicotine than common North American varieties such as N. tabacum. Other reasons for its shamanic use are the comparatively high levels of MAOI beta-carbolines, including harmine, harmaline and tetrahydroharmine.[2]

SHAMANIC TOBACCOS
Tobacco smoking was widespread in North America at the time of the European contact. While the habit of taking hallucinogenic DMT-containing snuffs was also prevalent in the Caribbean cultural area, there are no confirmed reports of materials other than tobacco being smoked.
The high culture of the Maya that flourished until the mid-800s in Mesoamerica had an old and complex relationship with tobacco and the habit of smoking it. The tobacco of the Classical Maya was Nicotiana rustica, which is still in use among aboriginal populations in South America today. This species is much more potent, chemically complex, and potentially hallucinogenic than the commercial grades of Nicotiana tabacum available today. The difference between this tobacco and cigarette tobacco is profound. This wild tobacco was cured and rolled into cigars which were smoked. The trancelike state that followed, partially synergized by the presence of compounds that included MAO inhibitors, was central to the shamanism of the Maya. Recently introduced antidepressants of the MAO inhibitor type are distant synthetic relatives of these natural compounds. Francis Robicsek has published extensively on the Mayan fascination with tobacco and its chemical complexity:
It also must be recognized that nicotine is by no means the only bioactive substance in the tobacco leaf. Recently alkaloids of the harmala group, harman and norharman, have been isolated from cured commercial tobaccos and their smoke. They constitute a chemical group of beta-carbolines, which include harmine, harmaline, tetrahydroharmine, and 6-methoxy harmine, all with hallucinogenic properties. While to date no native varieties of tobacco have been analyzed for these substances, it is a reasonable supposition that their composition may vary widely, depending upon the variety and growth, and that some of the native-grown tobaccos may contain a relatively high concentration of them.8
Tobacco was and is the ever-present adjunct of the more powerful and visionary hallucinogenic plants wherever in the Americas they are used in a traditional and shamanic way.
And one of the traditional uses of tobacco involved the New World's invention of the first enemas. Peter Furst has researched the role of enemas and clysters in Mesoamerican medicine and shamanism:
It has only recently come to light that the ancient Maya like the ancient Peruvians employed enemas. Enema syringes or narcotic clysters, and even enema rituals, were discovered to be represented in Maya art, an outstanding example being a large painted vase dating A.D. 600-800, on which a man is depicted carrying an enema syringe, applying an enema to himself, and having a woman apply it to him. As a result of this newly discovered scene, archaeologist M. D. Coe was able to identify a curious object held by a jaguar deity on another painted Maya vessel as
an enema syringe. If the enemas of the ancient Maya were, like those of the Peruvian Indians, intoxicating or hallucinogenic, they might have consisted of fermented balche (honey mead). Balche is a very sacred beverage and it may have been fortified with tobacco or with morning-glory seed infusions. Datura infusions and even hallucinogenic mushrooms may have been taken in this way. Of course they could also have used a tobacco infusion alone.

Mapacho , Nicotiana Rustica :



http://en.wikipedia.org/wiki/Nicotiana_rustica

EDIT : The author of this WIki article seems to have misread the source he cited