Is there any evidence at all for or against the idea of using a 1% solution of harmaline•HCl as a daily ear wash for ear infection?
I periodically get ear problems and would like to avoid repeated antibiotics use, and harmalas are known broad spectrum antibacterials.

I don't know evidence but i know some people used to to an oil extraction from seed (like olive oil or coconut oil) and use it as antibacterial.
I personnaly use it with coconut oil and rue seed for skin problem, small cut from razor and i'm confident with it.
How i do is, put seeds in a jar, cover with your oil, then let for 30 days full sun exposure (like spagiryc oil tincture). Be sure you jar can close hermetical, then shake once a day, then filter before using.

I've heard of people using rue that way, I never was sure how much would be from the oils or from the alkaloid salts. That's always topical, though.
Its probably a cultural bias but I get very nervous pouring anything in my eyes or ears

I suppose older folk remedies are likely whole spectrum extracts from the seeds/plants. But testing with mainly one alkaloid in particular is also interesting for sure.


About concern what can go wrong with Syrian Rue, there's a document in attachment about it, the doses they speak of is actually ridiculous high to what we're used to and it's consumed, still non lethal in the end (with the exception of being an abortifacient due quinazolines).
In an ear it's more of a local effect. In eyes I would be more suspicious.

Yes, I remember sheep testicle boy. That case report is so classic.

For the record, I am not planning to try it in my eyes, no matter how awesome that might be right before a black light rave

If the infections affect the ear canal (otitis externa- like swimmers ear) as opposed to the middle ear (otitis media), and you wish to avoid antibiotics repeatedly perhaps consider a solution of 2% glacial acetic acid for when you have symptoms. In the UK a preparation called EarCalm contains acetic acid and is available over the counter; its a reasonable first-line treatment (provided you're not allergic to it!).