See attached for an overview I like. There is a guy who took 2 pounds of sheep balls and then 150g or rue seeds
Unless you are a pregnant woman I think the seeds are OK. However, if one has a sensitive heart it may make sense to remove the quinazoline alkaloids
vasicinone and
vasicine as a precaution since they have both cardiac weak-stimulant and depressent effects respectively (I'm not sure though).
I'm not a medical doctor, so take this info as is based on the links and attachments.
If you take the seeds there should also be harmalol in them, which could be a bonus (?). We've been able to extract harmalol from rue seeds and obtain an MS peak for it here at the nexus thanks to endlessness and others, but this is not an easy process at the moment as harmalol is a zwitterion unstable in air. For now, any harmalol is lost during our classic extraction protocols (Harmalol would be discarded during the first alkaline water dump).