In my experience, really all hallucinogenic and psychedelically mind-altering substances seem to produce a sort of reverse tolerance or enhanced sensitivity to themselves and one another that continually deepens after every experience relative to the strength of that experience. That is to say, it's not surprising to me that having a powerful breakthrough experience on one powerful psychedelic substance could lead you to have a normally uncommon breakthrough experience on another relatively more mild psychedelic substance, especially if the first trip was still relatively recent.
I have always been sensitive to the dissociative effects of THC but over the years it has still developed further to become one of my most cherished psychedelics when it really shows itself. I have also had a handful of complete out-of-body experiences with entity contact as well as countless very powerful and vivid even if often somewhat faint visions using it in the dark when going to bed in the way that FranLover describes. I still smoke very often and usually don't expect it to be this powerful when just going about my day due to my high tolerance but still find it to have a very psychedelic headspace nonetheless that alters my perception and thinking style a lot more than I think I appreciated when I was younger, or perhaps it really just has changed that much.
Stronger substances that are still generally less overwhelming than something like DMT by default have benefited tremendously from this sensitization for me as well, and it's really become one of my favorite things about these substances in general. Reaching this point helped me to get over my younger insecurities about things like not getting enough visuals or an interesting enough mental trip and just enjoy each and every substance to the fullest for what it is; it's hard to complain when even low dosages of the classics or plants or research chemicals typically known for being very light are capable of taking you to those inner realms to mind-blowing effect all the same.
I tend to suspect that it has to do with how these "breakthrough" qualities are not really inherent to the drugs themselves but instead just reflective of certain perceptual "breaking points" our human consciousness reaches that can be breached in several different ways and which the brain can learn to give way to more readily with repeated experience, similarly to learning to achieve sober out-of-body experiences over time through patient meditation and guided attention practices. Once you've really got it figured out to the point that it becomes second nature, you just slip into that state readily in any sort of psychedelic or hypnotic state, and even just one or two very powerful experiences can really rip open your third eye to those possibilities and leave you quite sensitive for a while afterward.
That is my perspective on the matter anyway.
