Yes, but it depends on ROA, set & setting etc.
For example, people I have given pure DMT have been blasted in hyperspace and had hard time to absorb the experience, but they quickly returned to norm in the same day. The effects were more lasting with mushrooms.
However, DMT after oral harmalas had much more profound effect. People reported having more energy, being more sexually active and having better sleep for a week after the session.
There are first hand personal reports from people I know. I believe you will find more reports on Erowid and here.