Well, to bring this topic back, I would like to ask : WHAT NAUSEA?
I've never had nausea with any dose of mescaline. And I am almost sure nobody will experience the nausea if these rules are followed :

1. Use pure (white) mescaline HCl extract (HCl is very water soluble)
2. Use rectal ROA (2ml syringe is enough for almost any dose of HCl)
3. Use sterilization - for syringe, water, shot glass, ... (microwave oven is ok)

I understand some people are refusing this ROA. But, only because we don't see there and usually it is one way road, it is not wise to deny it. This ROA is gold. If done properly, the application is without any unpleasant feelings, it is done within 1 minute and it is safe. Bioavailability for mescaline is good, some say there is potentiation up to 3x, some say 2x, some say no potentiation at all, my experience is there is none. The comeup is faster, first alerts at 30mins mark, within 1hr it is already quite strong and 2hrs in is full-on ride. The experience seems to be slightly shorter, which is positive.

So the only disadvantage I am aware of is the application, which will mostly be done intimately, so it can't be done like sharing a cannabis joint with bunch of friends. Although, this is not true for sexual partners, where it can be even better than just sharing the joint

And last bit : this ROA is applicable to dmt too. Harmala extract (100mg) or moclobemide(150mg) orally and dmt(60-80mg fb) rectally 20 minutes later leads towards clean experience, without any stomach problems. Here the potentiation (for me) is 3x, for strong doses first "alerts" withing 3-5mins, hyperspace in 15-20mins, first contact with reality >1hr, fully back after 2hrs.

Did you say p.r. as per rectum or taken rectally?

Sorry, I didn't get the question...?

You made me smile and chuckle. So, I call that a win for the both of us.

Keep firing away my friend.

I don’t get nausea from crystal so it’s a moot point for me, however I’m curious about how much shorter your experience is? What’s your doseage and when are you asleep afterwards?

Usually I go ahead at 9am. For 600mg, at 16:00 I am 3/4 back. At 19:00 it is over. Sleep is without problems aftewards.

That is a short duration relative to dose. If I dose at 9am with 600 I’m back to reality by 17:00 but no chance of sleep untill at least 1:00 next morning. Usually 15hrs. Lower dose and maybe 12 hours total. It’s a very distinct dopaminergic AWAKE for me.

The question is whether the ability to sleep is due to shorter duration or some personal physiological setting.
Anyway, I have noticed shorter duration with this ROA for any chemical - mescaline, dmt, 2c-b, mdma and other. Usually it is shorter by 1/3 to 1/4.
For other substances it is rather unwanted, for mescaline appreciated.

Anyway, I have always zolpidem or similar chemical at hand, in case of any problems. Thankfully it is not necessary (for me) with rectal mescaline.

I have had it with massive doses of cactus.
With normal doses it is rare for me.
With intermediate doses I tend to have a little nausea in the first 20 minutes but nothing too bad.

This doesn't include that some teas and cactus flesh are so bitter that the flavor can cause gagging and make the air literally taste sweet by comparison.

If you are using whole cactus just remember to take the spines of first ;-)

Not necessarily, a bit of excitement never hurts. Some suggest short spined pachanoi, but I strongly suggest long spined peruvianus. My favorite choice

I did try with bufo alvarius and now my arse keeps croaking ;-)

Think I am going to have to work on improving my technique.

what concentration of solution do you prepare for your syringe and how much solution
have you found increased efficacy post enema?

have you explored dosages of 1-2g?

I usually do 300-400mg of mescaline HCl in 2ml of water. Max I've done by one injectiton (2ml of water) was 600mg. Mescaline HCl is used due to its very good water solubility

Some people say rectal ROA increases potency compared to oral ROA, some that it decreases. I don't have many experiences with oral ROA because I don't like the body discomfort, but from my experience I would say rectal ROA doesn't increase the potency, rather slightly decreases.

No, I still have to experience dosage over 1g. But it is planned

If I wanted to go with let's say 1,5g, I would divide it into three 500mg doses and inject them with 15-20min intervals

thanks for the response pete!
usually these gram + dosages have a different type of nausea for me.

phenethylamine nausea is unavoidable at certain doses from my experience,

i once insufflated 2 mg of 25i in saline solution w no tolerance, within 3 minutes i was on the floor throwing up like i ate a tub a niacin, nothing was in my stomach either. i had just woken up and decided to get slathered up the nose.

separately i once smoked yopo extract on shrooms and threw up within a minute, totally fine before that

since then theres a slight discernment between tummy nausea and phenethylamine nausea

No problem Chaska.
If we talk about more than twice the usual strong dose, this reaction is always possible. This can happen for any drug, especially hallucinogens. Brain experiencing such change in perception can evaluate that situation as an actual poisoning and try to reverse it by vomiting. I doubt any ROA can help against that

thats kind of what im thinking ^^ oral dmt can do it too

it is worth noting that the tea administered as an enema was nausea free, which in itself makes the experience much more friendly. however i didnt achieve the normal strength on the dose compared to oral ingestion

What about body load when using this ROA?

The body load is the same for oral and rectal roa, if we do not take the nausea into account.