Which psychedelic or psychedelics are the safest physically? I don't want to discuss the mental aspect for the purpose of this thread, just physical.

I've only ingested psilocybin, dmt and lsd so far, and I'm wondering if those are the safest and if there are even safer ones. Out of these three which is the safest?

I vote for DMT!

Cannabis edibles

Definitely mushrooms, then DMT.

The LD50 for LSD (in rats) is 16.5 mg/kg.

The LD50 for THC (in rats) is 105.7 mg/Kg.

The LD50 for DMT (in mice) is 110 mg/kg.

The LD50 for Mescaline (in rats) is 132 mg/kg.

The LD50 for Psilocybin (in rats) is 280 mg/kg.

Personally DMT because of the short metabolizing time.. and the state it leaves you in after..
At least me when doing mushrooms or lsd, first of all the body load and the duration.. and the day after is similar to a hangover day which I do not like at all..(of course I love them anyway ) with the medicines in the DMT category it is reversed.. the day after you feel better than before..

The ld 50,s for these compounds are so high so it is in some sense irrelevant... but good to take a look at

Pharmacologically LSD, DMT, mescaline, and psilocybin are all extremely safe.
If a glass of water were one dose of water then its literally easier to overdose on water than LSD as only 30 or 60 doses of water will mess you up and 120 doses of LSD just gives you a story to tell your grandchildren.
However, all that is assuming the drugs are pure and correctly identified. If your "LSD" is really an NBOMe or your "psilocybin mushrooms" were sprayed with some type of RC then those drugs dangers, obviously, come into play. You really dont want to OD on an NBOMe.
This is a major reason psychedelics should be legal.

I believe that is all just a major reason for people to grow and produce their own safe psychedelics more so than to be made legal. Legality would mainly serve the purpose of ending the witch hunt of people who grow and create these substances, which would be beneficial for many people.

I'm not sure I'd like the governments who have continuously shown they are control freaks who regard us as experiments to get a hold of psychedelics. It wouldn't surprise me if people start getting sick of all the cannabis from legal dispensaries, nor would it surprise me if they attempted the same with psychedelics and stimulants like mdma.

Breathing techniks

I hear there's no known LD50 for man and LSD... and you'd have to consume near 2/3 an ounce of pure mescaline to OD... anything natural, and with shamanic history is generally the route to take though: richer content than LSD or other, more dangerous RC's

At 16.6mg per kg I would have to hit moar than 1.5 grams of LSD to hit the red line. Like 1500+ trips.

Not sure whether I would break that up in 2 lines or just go the one one Big Kahuna.

this question is really tough to answer because it would all come down to what you define as "safe" and "safer". I would say generally speaking dmt and mushrooms are the safest for the brain but i honestly dont know what would make things like mescaline and lsd any "less safe". maybe in reality they are all just about as safe as the next? hard to say really.

I think there are two aspects:
Purely relating on normal dosage vs LD50 (estimated) LSD is probably the safest. But the needed dosages are very small. So it is theoretically possible to ingest such an amount.

E.g. ODing on shrooms is IMHO simply physically impossible.

Also ODing e.g. on DMT, even if pure, I would think is rather impossible (without MAOI), also because of the huge immediate tolerance build up. So IMHO you just cannot get such a lot of DMT in your system in such a short time. But maybe I'm wrong...

Eating a whole tablespoonful of DMT fumarate might be interesting, it could potentially overload the body's MAO capacity. A bit inefficient though.

I think some psychedelics for sure.

Especially the ones that incapacitate you so you cant hurt yourself or do crazy stuff while tripping

What is the definition of safe?
Safe from death or from mental disease?
Safe from delusions about how the life works, what role nature plays in the awakening of higher mental states and the sentiment of isolation and sadness of how the human world functions? Safe from the realization that we are all giants, raised by pygmies and don't know how getting out of this prison?

I tend to say that LSD and psilocybin are good substances to start with, under prescription that they come from a known source. They are transparent in the sense that they can be adapted to a huge spectrum of settings, LD50 is relatively low and they combine spiritual insights with that hedonistic ambience, where there is always a laughter. For starting, I think it is helpful to see that psychedelics are fun in some sense also and not only hard spiritual breakthrough -in some way it is good to see that "god" has some sense of humour, too.

DMT is safe on a physiological level, but its impact on the mind is something hard to digest. I am glad I haven't started with this molecule.

So, for me mushrooms are a good starting point, especially when grown by yourself for higher energetical exchange with the matter. LSD, you always need to buy from somebody. Mushrooms are at the forefront of independent psychedelic investigation, a real graal to autonomy.

If you want to be safe from delusions, try icecream

Noooo, icecream is just an agent to push you back into the program capitalism next too coffe and alcohol! and the LD50 for Ben and Jerrys are probably lower than these compounds!


[quote=donfoolio]What is the definition of safe?
Safe from death or from mental disease?
Safe from delusions about how the life works, what role nature plays in the awakening of higher mental states and the sentiment of isolation and sadness of how the human world functions? Safe from the realization that we are all giants, raised by pygmies and don't know how getting out of this prison?

LOVE IT!!!

I'd always heard that the lethal doses for all of these substances (non stimulant psychedelics) and marijuana was around fifty pounds regardless of body weight.

Dropped upon one's head from a very tall structure.

This is such a beautiful way to die

After highsdosing LSD for many times i am some kind of in doubt about that...