Your primary reference here should be Jonathan Ott's [i:af627012b6]Ayahuasca Analogs[/i:af627012b6] in which he details his bio assays on achieving an optimal dose for syrian rue in combination with both dmt-hcl and various dmt-containing ayauasca analogs. He settled on about 3g of rue. There are other reports (e.g. the phalaris faq and Gracie&Zarkov if memory serves...) that corroborate Ott in that more than approx. 3g doesn't appear to effect the oral efficacy of dmt. Both Ott (Ayahuasca Analogues) and Shulgin (TiHKAL) sensibly recommend preparing a diluted hot lemon-juice extract of the ground seeds, since, as Ott has pointed out, a record of safe use of an extract of something in no way indicates safety for the plant material itself, since extraction effects a separation. Ott specifically referred to mhrb and syrian rue in this context, and mentions that rue contains uterotonic quinazoline alkaloids in addition to B-carbolines, which are mostly left behind when extracted. cf. the last paragraph of this valuable resource entitled "Pharmahuasca: On Phenethylamines and Potentiation": http://www.maps.org/news...ters/v06n3/06332ott.html Here is a summary of Ott's recommend extraction technique: approx. 3 grams of seed are thoroughly ground, briefly boiled in a 1/3 lemon juice 2/3 water mixture, and filtered through a coffee filter. The solid remains are extracted a second time as above and the resulting extract is added to the first. This may then be reduced to provide approximately 100-150 ml of extract and drunk. wishing safe journeys -z