this is from drugs forum..
If you mix 2 parts ground turmeric with 1 part ground black pepper and put it in a capsule you can feel the curcumin.
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When using black pepper to boost the effects of curcumin orally by 2000%, you only need 400 mg of black pepper (about 1/4 tsp). Black pepper usually contains at least 5% piperine, and often more. All you need is 20 mg of piperine to boost the effects of curcumin orally. 400 mg of black pepper at 5% piperine contains 20 mg of piperine.
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Maybe if curcumin is combined with piperine orally it can activate DMT orally. But without piperine, I'm pretty sure it's not going to work unless you take a ton of curcumin. Without piperine, you need to take 20 times as much curcumin. So if say 500 mg was enough for MAOI activity with 20 mg of piperine, then on it’s own you’d need 10 grams of curcumin! So, I wouldn’t even bother using it orally without piperine.
Duration
The effects only last about 4hrs tops. So it is necessary to keep re-dosing if trying to achieve some kind of long-term therapeutic effect.
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. from my experiences, 1-2 huge spoonfuls of Turmeric powder + 1 small spoonfull of ground up black pepper really helped me with SA. of course, its a very Weak MAOI...but it also has neuroprotective properties, and is an NMDA antagonist.
It helped me alot last school year, the downside being, the effects only last about 3-4 hours after dosing. So every 4 hours you have to re-dose (swallow more of the turmeric powder, i chugged it down with milk, it wasn't too bad)
Experiences
The following is simply a compiling of various reports in effort to describe the effects of Curcumin (Tumreric). These reports largely do not reflect in a therapeutic sense, rather just "feelings" or effects noted.
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I tried a single dose of Curcumin several days ago. 300mg Solgar brand Tumeric from Whole Foods, 95% Curcumin. Lunchtime dose.
It was a bad day to start with. The hours after the dose, it just got worse. I felt more tired, more depressed. Any bit of forced energy or forced motivation I had just evaporated into dark survival. I just couldn't wait for bed to get it over with.
Oddly, I couldn't fall asleep. I always sleep good. I tossed and tossed. It felt similar to that serotonin/norepinephrine/dopamine stimulation I have felt on various psych drugs. After 4 hours, I finally gave up and took a half of a Benadryl. It put me to sleep in about half an hour.
The next morning took me by surprise. I woke feeling a kind of refreshed "it's a new chapter" kind of feeling, the same thing I felt after my first dose of the MAOI antidepressant Parnate.
About halfway through the morning I felt warm, energetic, and clear headed. My weak rubbery legs had bounce and energy. Pains from Lyme disease were nearly gone. My brain fog turned into crystal clear seeing and thinking. Sharp. My appetite was down. There was absolutely no doubt Curcumin had an astounding effect that took me totally by surprise.
All over the net it is claimed there are no side effects. I found that laughable. My side effects were: Appetite supression; anxiety (the chest/belly kind); and insomnia. My friend at another forum said insomnia was the side effect he couldn't handle. I can see why.
The benefits though were huge. Depression went from a monster to a whimper overnight. Energy went from the dumps to the clouds. Fog totally vanished. Instead of avoiding people and conversations, I was actually approaching people and conversations.
I am thinking of retrying it, but starting at a much lower dose and working my way upward, with customized home-made doses.
One-time fluke or real potential? Dunno. We'll see. All I can tell you is that nothing, absolutely nothing, out of dozens of herbs and dozens of psychiatric meds, have impacted me in such a positive way so rapidly and unexpectedly, except for Parnate. It is curious to see that one of the claimed actions of Curcumin is a MAO inhibitor. That's what Parnate is.
Back to your original question, one study I found showed that Curcumin enhanced the effects of subclinical doses of Prozac and a couple other antidepressants. Based on that, it would appear to me it is safe to combine with SJW. If you do it, I would go into knowing that the hype on the net about no side effects is a bit negligent in my opinion.
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Turmeric Root (active ingredient = curcumin) it is an MAO-A inhibitor. However, it is not absorbed by the body, unless you take it with Piperine (Black Pepper, the stuff in your cupboard hopefully) . from my experiences, 1-2 huge spoonfuls of Turmeric powder + 1 small spoonfull of ground up black pepper really helped me with SA. of course, its a very Weak MAOI...but it also has neuroprotective properties, and is an NMDA antagonist.
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I took curcumin for years for pain in my joints. Eventually, those pains went away. So I stopped the curcumin. After this, I realized during this time, I didn't experience random episodes of depression. After I stopped supplementing with it, those depressive episodes came back. I little research on pubmed shows that Curcumin is a potent antidepressant. It is also a great anti-inflammatory, immune modulator, is neuro-protective and many other functions.
Curcumin is also used for patients with Alzheimers disease as it reduces the amyloid plaques that develpop in alzheimers patients. We've found in this forum that things that help alzheimers patients, like lecithin and choline are also beneficial to us. Curcumin also acts as an MAO-B inhibitors. This is what breaks down serotonin and other neuro-transmitters in the brain. Curcumin increases glutathione in the brain....Also, curcumin is typically use against cancer...Curcumin can boost the immune system and has anti viral, bacterial and fungal properties.
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One size 000 capsule orally is enough for a smooth slightly dreamy effect for SWIM. It's very mild though. Others might need a few capsules. But it definitely works orally this way. The effects sort of remind SWIM of marijuana, or maybe like passionflower at this dose. It's very mild.
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Turmeric is indeed active and very much so, I currently have a medium intense foggy, dreamy state with a rather good body euphoria after eating four 000 capsules with turmeric and two with pepper. I also have a small headache and a bit stomach upset, nothing intense, but I think my next trial will be with an extraction.
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The tincture was ~35ml and SWIM took 5-6ml sublingually. it did not burn like many sublinguals and tasted like turmeric.
after 15 minutes SWIM spat it out and after 20 he felt "something"
At present he is at t=+1:20 and he is very effected. No question this is beyond placebo.
The effect is much like syrian rue (the only harmala he has experienced) except it seems to be stimulating as opposed to sedating.
SWIM started to sit down to watch TV and is pretty on edge. This dose is very strong in fact.
Despite no tracers or visuals (SWIM never got those with rue either) colors and lights are very bright/brilliant.
It took SWIM a ridiculous amount of time to write this down, his mind is very effect and he is beaming.
SWIM plans on testing the combination with DMT and SWIM's roomie will test it with weed (SWIM hates weed) and we'll update later.
Cheers
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There is no doubt in SWIM's mind this is beyond placebo, 3 cases of effects on very reliable sources.
if SWIM wasn't so very high on mescaline (oops) he would love to pursue this further and he is quite confident this will turn out to be a great combination for MANY drugs.
It is a stimulating MAOI, kinda like THH and SWIM hasn't stop hearing about the wonders of THH.
Negative Experiences
This is a good example why MAOIs should not be messed with particular other drugs.
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id be really careful, u dont wanna end up throwing up in the toilet for 3 hours like me. i took a reversible MAO-A inhibitor (curcumin) with Effexor and got really really bad serotonin syndrome. SS stinks.
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but not only did i take a TON of Curcumin (MAO-A inhibitor), i took it with piperine which potentiates Curcumin greatly, and also has weak MAO inhibiting properties. And i took that stuff with Effexor...but then i also took 3 capsules of Bacopa Monniera Extract...after doing alot of research, it seems Bacopa might be an unselective serotonin agonist. no wonder i got SS.
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