I would like to make peace with anyone I offended. I am embarrassed that I offended anyone. My strong feelings for kratom are most likely due to the postive effects that this herbal medicine has had on me. I can take kratom every day for months then go 4-7 days sometimes months and never experience withdrawal.

I live in fear that the powers that be will outlaw this wonderful tree, taking away a medicine that helps me so very much.

I can understand that some people might have a negative reaction from kratom especially if combined with other drugs. Kratom could be fatal to a person much like a peanut can kill.

"Somewhere around 150 to 200 people die in the U.S. each year because of food allergies. It's estimated that around 50 percent to 62 percent of those fatal cases of anaphylaxis were caused by peanut allergies. "https://health.howstuffworks.com/diseases-conditions/allergies/food-allergy/peanut/how-many-people-die-each-year-from-peanut-allergies.htm

Hamiltons Pharmocepia is airing a new episode on kratom next week I think December 12, on vice tv . I have been told it can also be viewed on youtube maybe a few days in advance.

accept me or reject me

peace

If something like kratom destroys your life then you're probably a loser. The only reason why it destroyed you is because kratom got there first. Of course I'm not talking about negative reactions with other drug's. I've used a lot of drugs in my day and kratom is nothing, NOTHING!!! Another thing, if you're at home extracting DMT and you think kratom user's should be locked up in a cage then you're being extremely hypocritical.... Sorry im just angry about this Kraton ban ...

I know I am late to this discussion, but...



Has anyone considered that the victim aspirated on their own vomit? Many deaths attributed to opioid overdose are actually the result of this. This is why I always recommend that anyone who is intoxicated and about to pass out lie in the recovery position.

Either that, or the additive CNS depressant effects of alcohol combined with mu agonism, resulting in severe respiratory depression. If kratom alkaloids are a2 agonists as this paper suggests, that would further contribute to the sedation and orthiostasis, along with the strong h1 blockade from the benadryl and mirtazapine.

For the nth time everyone, DON'T MIX DEPRESSANTS!!! Please & thank you. RIP to the deceased, but hopefully this story can prevent at least one overdose.

Thank you for adding your input to this discussion!

It is most likely that the victim did indeed die from aspirating/asphyxiating on their own vomit during sleep (in a manner similar to how John Henry Bonham died). Kratom (via opioid receptor activity and GI irritation) and ethanol both promote emesis (yet ironically enough diphenhydramine and mirtazepine may produce anti-emetic effects via modulation of histamine activity). I, too, would hypothesize that the victim vomited during sleep, and died of asphyxiation as it

Also, adrenoreceptors (alpha 1 & alpha 2 in particular) have multiple binding sites, and can product both excitatory and inhibitory effects depending on exactly how the drug tickles these binding sites. It is a very complex subject, especially given that mitragynine bears a strong structural resemblance to yohimbine. As thus, I would be hesitant to bring the noradrenergic features of this OD into play just yet, especially so given that ethanol itself has profound effects on noradrenergic neurotransmission, as well.

I wholeheartedly agree with you on not mixing CNS depressants in such irresponsible manners, as well as advocating that those who do sleep in the recovery position under tight supervision. My well wishes and prayers go out to the poor victim and his family.