Studies using LSD, psilocybin and Ayahuasca have shown that the effects of psychedelics on blood perfusion, functional connectivity, spectral and BOLD activity are reliably captured in a safe manner in brain imaging environments. However, the slow onset and long duration these drugs have, render the study of transitions between the normal waking to the psychedelic state a difficult challenge. In this study a potent and short-acting psychedelic drug, N, N, Dimethyltriptamine (DMT) was used to capture these dynamic transitions, while EEG was recorded and subjective responses were collected during the onset, offset and peak effects of the drug by administering three different doses of DMT fumarate (7mg, 14mg and 20mg) and placebo intravenously (IV) to healthy participants. The results from the neural and subjective effects will be discussed as well as assessing the safety of IV administration of DMT in imaging environments.