Maybe not a FAQ but still...
What the FAQ? Please Do Some Research... There is stuff to be found about piperine if you have a look around the forum and the internet in general.
Piperine inhibits at least one CYP450 subtype and activates the P-transporter protein. Have a look at the metabolism of your nootropics and see if any of this overlaps. As for "other substances", each of these would have to be researched in a similar fashion. Just say know.
“There is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work."
― Jacques Bergier, quoting Fulcanelli