I have microdosed LSD and mushrooms before, both with positive results. Subtle change in mood and much less reactive. I find I am that way when I am stoned on weed anyway. In my book, weed = microdosing LSD or mushrooms. Same kind of easy going feeling.
I agree with GuruD as well. One large trip can have some very positive results as well. It just requires much more attention and energy.
The microdosing is good maintenance and the large dose trips can change you fundamentally. Combine both into your life and it's a powerful tool when you need it.
I think microdosing is more palatable for a wider variety of people. Some people can't take the strains of a higher dose. It can overwhelm some people, including myself a time or two, lol. I think they both hold great value in there own way.
"In the universe there is an immeasurable, indescribable force which shamans call intent, and absolutely everything that exists in the entire cosmos is attached to intent by a connecting link." ~Carlos Castaneda