Looking at this thread, people say that 100-150mg of DMT is where "the magic starts" with pharma:

https://www.dmt-nexus.me....aspx?g=posts&t=9120

Yet when it comes to mimosa, people claim that using 15g is insane.....what's the deal?

Is one really losing that much potency when extracting from mimosa for pharma rather than drinking the mimosa?

Personal preference & body chemistry comes into play here.

For me, even 100mg DMT is a bit much when dosing pharma. I can breakthrough usually around 250mg harmalas & 75-80mg DMT.

With brews there seems to be a little more than just DMT going on, but then the dose of mimosa also depends greatly on how well you brewed the bark & the amount of alkaloids available to pull out in the first place.
Sometimes 10g worth of mimosa is sub breakthrough for me still, other times 5g is over the top.

You really just have to start low & get a feel for your materials potency wise. Large batches work best IME because you have enough to start very low & titrate up over the course of several experiences without running out & having to start over again.