Thanks very much! I will post more as I have more experience, this thread and others I've read gave me a lot to think about fo my next extraction. I'm planning on doing a crude harmala extract on the rue and to use better filtration techniques with acacia. If I still can't stomach that I'll try evaporating and gel capping. Sometimes just tasting something I've associated with vomiting is enough to make me nauseous!

I've never had caapi, but know people who had. They claim caapi alone pass 50+ grams feels similar to high doses of rue. The differences in the head space are subtle, but the body load is pretty much the same. Both will make you shiver, cry, puke and shit if the dose is high enough.

IMO an overdose is taking so much that you end up being in a physical danger. People generally think you're supposed to feel very bad on ayahuasca because it is an essential part of the cleansing process.

I don't agree... Sure, some discomfort is called for to get rid of all the nasty stuff you body has been building up but you don't even have to puke or have explosive diarrhea for that. My personal sweat spot for harmalas is just slightly above the range that is enough for full mao inhibition so that no DMT is wasted and you get a slightly dreamy effect from it. Why would anyone even need more? Increasing the dose will just increase the body load, and even if it gets significantly psychoactive by itself you might be in the toxic range.

This also leads me to a point I forgot to mention. Even pure DMT is known to cause some nausea when orally consumed, but I've had brews that were quite manageable in the nausea department yet powerful enough so I'm gonna go for the classic "be sure you know how to brew and filter it out properly" advice for this guy.

Brewing any sort of ayahuasca analogue is not hard to fuck up at all, so be sure to watch out for details that contribute to the body load. Maybe it is experience, maybe the body adapting to the molecules or a combination of both but IME and I've heard this from a lot of other people the body load gets less and less severe the more you brew it.

For those not opposed to pharmaceuticals, moclobemide(150-300mg) is an effective RIMA with low potential for nausea. As a "prescription" med it's not available in USA, however there are simple modes of acquisition for those so inclined. Ondansetron(Zofran), 5HT3 blocker, is another pharmaceutical with effective anti-emetic(nausea) properties, particularly the centrally mediated(as opposed to gut) nausea caused by tryptamines. It doesn't block the psychotropic effects mediated via 5HT2 receptors. FYI

Peace