I'm primarily interested in how such things affect cognition, mental health etc. I have heard about some shamans drinking ayahuasca everyday for 20 years in the amazon.

I thought that I actually have time for this to do every day, but I don't since it is very intense and too much too handle too frequently but could someone get used to it and actually gain benefit?

Interesting thing I heard from ayahuasca is that if I want maximum healing to just keep drinking, it didn't specify for how long and how frequently but that message was pretty clear and straightforward.

Can someone get used to it a bit to do it more frequently or this a drug that turns on you when you do it that often?

The reports I read suggest DMT has a reverse tolerance while harmalas require more each dose. Either way, are you sure you want to be taking full doses everyday? There is a high chance due to synaptic plasticity that if you do it long enough, the trips might end up compounding on top of one another until you might not feel normal for at least a month or so?

I mean, I don't think the more you take it daily the more you will get used to it, it is more likely the more you take it every day the more difficult or bizarre your ordinary reality will be to deal with. That might be individual dependent though.

Microdosing on the other hand is win.

I never said I would do it, only that I could if I wanted to. That being said I do think I might be doing it to frequently.

I always liked the clarity and positivity afterwards and I want it to intensify and stick with me for longer. It always seems like I'm close to where I want to be in life but not quite there even though I break through with my trips.

My co-workers have commented that they never met anyone as calm as me and that it is unbelievable to be as centered.

I guess this aproach is good for now? Do it frequently, but not daily and stop eventualy? Aya never struck me as a recreational drug, even at low doses and I always had the feeling I wouldn't drink this stuff my whole life.

Both is not true. Vaporized DMT will hit everyone if vaped correctly. Just takes most people a while to figure out how to do that hence the "reverse tolerance".

Harmalas in your blood increase if taken daily, even small doses. Thats true with every compound with a biological half-life. If we assume a biological half life of 6 hours for harmaline, there will be still 6% left after 24 hours which get added to your new daily dose.

Many people are drinking ayahuasca daily, semi-daily in varying doses.
I think jamie did it for a while but not 100% sure. Otherwise, there are plenty of microdose threads for your enjoyment around

Oh wow I thought about daily DMT too and the Impact of it on your mind

Also both DMT and harmaloids will have more pronounced effects on the regulation of genes for the expression of CYP metabolic enzymes if dosed daily (if I've been following such things correctly). This epigenetic phenomenon will in turn affect the half-life of harmaline for one thing. Here my confidence in making further inference falters for the moment.

the daily microdosing I wont go into here. I think many other people can speak to that.

Aside from daily microdoses, I think every night for a week was about my limit. It does get stronger in my experience.

Beta-carbolines building up over time in your system like that is not always pleasant.

Once a week was a routine for a number of years. It's become far less frequent.

What about daily ayahuasca use in specific would you like to know?

I'm interested in how does it affect you in your day to day life afterwards. Is it beneficial in the long term or is it pretty much the same thing as with dosing every once in a while. Ignoring the potency, I figured that one out myself but it was dosing every third day, not every.

The Tannins are harsh on kidneys and liver , every day for years is most likely just as harsh on the liver n kidneys as drinking alcohol heavily .


Ive drank Aya every day for like 2 months str8 . mix it up using egg whites to remove tannins vs not .

idk on the reverse tolerance, more less feels your "in" you can keep doing it everyday or as you see fit .

Kinda how it has hit me l8ly .

I think you have the terms mixed up. Reverse tolerance is when you become more sensitive to DMT.

So, of course vaporized DMT will hit everyone if vaped correctly? Reverse tolerance actually enforces that point so I don't see why you made it unless you misunderstood what it meant.

I have seen many people report that after have multiple breakthrough doses that they can breakthrough with less of a dose. It isn't so much in the synaptic sensitivity of the molecule but in the pathways that have been set by synaptic plasticity. If your neuronal pathways were roads, ingesting DMT would be equivalent to building a mass of new roads in fringe areas and then slowly over some weeks the roads fade away, if however there is lots of car activity the roads are strengthened and become more fixed and stable and more likely to have car activity.

As for harmalas, I can see there would be a build up of monoamines due to the pronounced effects on the regulation of genes which would increase half life but I still remember someone saying that after a few weeks of daily dosing he was taking well over a gram of harmalas and getting similar effects to when he first started at 300mg, I just can't find the thread because of the forums inadequate ability to search for related words (ie if you search for harmala it won't show any results for harmaline, which other forums do).

That report probably was a one off though because I have searched and nearly all have report reverse tolerance: "harmine/harmaline tolerance?

Yes, needing a smaller dose every time you smoke (reverse tolerance) vs needing a bigger dose everytime you smoke (tolerance).

I was claiming that reverse tolerance does not really exist, but people believe it does because they are not very experienced in vaping dmt. The better they get at vaping, the more dmt they are effectively able to consume.

E.G

First Try: 50mg loaded, 10mg vaporized correctly - Threshhold effects
Second Try: 50mg loaded, 25mg vaporized correctly - "Waiting room experience"

Conclusion: "There must be a reverse tolerance!"

There must not, you just got better at vaporizing dmt

In the past I went through a period of frequent ingestion of mimosa/rue, culminating in a weekend where I re dosed constantly for a 3 day period. During that period, I noticed a definite reverse tolerance and heightened sensitivity to all psychedelics. On several occasions during this time I took harm alas without admixture but still had trips very similar to if I had used admixture. Endogenous dmt theories abound..

At some point I got the idea that I could do this daily, but never managed to follow through with it. I did get the impression that you would definetly start going insane at least when compared to "normal" people

While I have not taken aya with a dmt admixture daily for longer than two consecutive days, I do have experience dosing harmalas (4-6g syrian rue tea) every weeknight for two weeks.

Whatever your goals for daily or near daily aya use are, you have GOT to take the time to integrate. ESPECIALLY with ayahuasca. I mean, if there is ANY psychoactive substance that requires proper integration and preparation, it is ayahuasca. Listen to your body and your mind! Not what you are telling yourself you should do, according to a schedule you made BEFORE. If it feels right, and your intention with taking ayahuasca is in alignment with growth, humility, and responsibility, I'd say, go for it!

In the case of the almost daily syrian rue tea, I also definitely noticed increased sensitivity as the experiment progressed. Towards the end, I was having deeply psychedelic experiences off of the aforementioned 4-6 grams. I think a great idea might be to gradually lower the doses you take as the sensitivity increases? Not at a point where I need any more tripping right now but I plan on exploring this idea and reporting back in the near future.

As time went on during this two week period, I noticed that I did not sleep as well. I had very vivid dreams, and would sometimes wake up still dizzy from the night before. Contrary to what you might be thinking, this dizziness did not make me nauseous. In fact, as my sensitivity increased, I actually found that I was a little more resistant to the nausea from the harmalas.

My dietary habits definitely changed. I simply began to crave nutrition more; I think harmala sensitivity increased my ability to listen to my body. I became disguisted by my usual eating habits.

I also really believe that during this period of two weeks, my capacity for empathy grew a significant amount. Even the usual things I do to waste time like browse facebook or the nexus took on incredible emotional significance. This increased emotionality definitely faded after the experiment had ended, but is still present and helping me strengthen my relationships with friends and family.

But you entirely skipped over this

Isn't there a difference between reverse tolerance and increased sensitivity to a compound? For example as I understand it with a molecule like salvinorin A the reverse tolerance is due to opioid receptors being upregulated after use, which means that next time the experience is more powerful. I don't think that happens with tryptamines, rather you learn what to look for and become more comfortable with the experience so you can further immerse yourself.

Chemically yes, but personal accounts of what it would feel like would be much the same. The sheer amount of reports of DMT, mescaline, mushroom & LSD sensitivity alone is enough to negate anyone who want's to say it doesn't exist (just search).

Sounds to me like three possibly complimentary mechanisms - improved technique, neuroplastic inverse tolerance and psychological openness (which may of course be a by-product of the preceding). These things can surely work together

I took sublingual doses of caapi extract a couple of times a day and vaporized several low doses of dmt, in the evening for nearly two weeks. I felt incredibly tuned in and happy at about the one week mark, but I went to far into bliss. It was awful. I was too happy and too connected. It was weird and really intense. I got a peek at what being a mystic or an ecstatic must be like, and I didn't like it.

I have a friend who is a mental health professional and I spent some time with her toward the end of this period. I asked her if I seemed manic. She said: "No, but you seem like someone who should stop taking psychedelics for awhile." I did.

I found that it got very strong toward the end. I got to the point where I could easily break through on 10mg. One of my most harrowing experiences ever was near the end of these two weeks, on 15mg out of a clean gvg and scrubby. Way more intense than my first time which was 65mg sandwiched in blue lotus in a pipe. Also more intense than 40mg with a good technique, developed over years, in a gvg. The 15mg toward the end of 2 weeks of caapi saturation, was beyond words. It had something to do with an ascension and knowing that there is no difference between life and death... but that's all I can say.

I plan to drink aya on a daily basis in the near future, for a week. Vine only.
So far, the most beneficial thing I've found is two mushroom trips, a week apart, every three months.

Wouldn't that suggest that the DMT breakthrough is not dependent on the molecule but on the brain? In other words, if was dependent on the chemical then it would be the same dose every time, but having a breakthrough at lower and lower doses every time seems to suggest the brain is just using the molecule as catalyst to breakthrough which it could do naturally if it could only find out how to do it.

Just a horrible idea overall.