it is highly probable that what people experience are the various vasoconstrictive/somatic effects from the inactive isomers.
those effects are visceral, not psychoactive nor imagined.

it is highly probable that what people experience are the various vasoconstrictive/somatic effects from the inactive isomers.
those effects are visceral, not psychoactive nor imagined.

it is highly probable that what people experience are the various vasoconstrictive/somatic effects from the inactive isomers.
those effects are visceral, not psychoactive nor imagined.

Would that also be true for other synthetic drugs?

And also, what causes these differences? Is it a matter of different precursors? I think it would make sense that natural precursors have different isomer ratio's than synthetic precursors as nature seems to have a preference for certain isomers.

Timothy Leary, who realized that impurities were a threat to the spreading psychedelic revolution, uttered prophetic words of warning at a Senate committee hearing in 1966, in exchange with Teddy Kennedy:

Senator Kennedy of Massachusetts: "What is it in the quality that you are frightened about?"

Dr. Leary: "We do not want amateur or black-market sale or distribution of LSD."

Senator Kennedy: "Why not?"

Dr. Leary: "Or the barbiturates or liquor. When you buy a bottle of liquor-"

Senator Kennedy: "This is not responsive. As to LSD, why do you not want it?"

Dr. Leary: "On possession?"

Senator Kennedy: "Why do you not want the indiscriminate manufacture and distribution? Is it because it is dangerous?"

Dr. Leary: "Because you do not know what you are getting..."

Despite Leary's warning, LSD was made illegal on October 16, 1966.
https://www.erowid.org/c.../lsd/lsd_writings1.shtml

Owsley's fellow alchemist, Tim Scully, admitted to me that the 1965 batch was impure, but claims that Owsley and he perfected a purification process in 1966. Many who used both Sandoz and Owsley - the latter came in tablets of purple (Purple Haze) and white (White Lightning) of 270 micrograms - say that Owsley acid was less mystical and had more stimulant side reactions than the Sandoz product. https://www.erowid.org/c.../lsd/lsd_writings1.shtml

Most of the books on the market that give details on the LSD process - for example, Psychedelic Guide to the Preparation of the Eucharist, by Robert Brown, Basic Drug Manufacturing and The Book of Acid, by Adam Gottlieb, as well as Michael Valentine Smith's book - fail to describe the efficient chromatographic procedures, like zone-melting chromatography, necessary for the manufacture of pure LSD. Timothy Scully told me that both he and Owsley believed the tolerable limits of impurities to be one tenth of a percentage point (requiring 99.9% purity) - far from the 50 percent figure of Michael Valentine Smith! Until careful studies are done, the true figures for tolerable impurities will remain unknown. https://www.erowid.org/c.../lsd/lsd_writings1.shtml

onvert iso-LSD to LSD. Add 50 ml of ethanol and 5 ml of 4 N KOH per every gram of iso-LSD. Let this mixture stand for 2 hours at room temp. Evaporate in vacuo to get the LSD.

Separate iso-LSD from LSD. Dissolve the residue of the mixture of LSDs from the end of the formula in 120 ml of benzene and 40 ml of chloroform. Add tartaric or maleic acid to precipitate the LSD, filter off, add a little ether and put in refrigerator for several days to get a little more LSD, which is filtered off and added to the rest. Evaporate the filtrate in vacuo to get the iso-LSD and convert as above.
from "Recreational Drugs" by buzz

: LSD is an unusually fragile molecule and some comments are in order as to its stability and storage. As a salt, in water, cold, and free from air and light exposure, it is stable indefinitely. There are two sensitive aspects of its structure. The position of the carboxamide attachment, the 8-position, is affected by basic, or high pH, conditions. Through a process called epimerization, this position can scramble, producing isolysergic acid diethylamide, or iso-LSD. This product is biologically inactive, and represents a loss of a proportionate amount of active product. A second and separate point of instability is the double bond that lies between this 8-position and the aromatic ring. Water or alcohol can add to this site, especially in the presence of light (sunlight with its ultraviolet energy is notoriously bad) to form a product that has been called lumi-LSD, which is totally inactive in man. Oh yes, and often overlooked, there may be only an infinitesimal amount of chlorine in treated tap water, but then there is only an infinitesimal amount of LSD in a typical LSD solution. And since chlorine will destroy LSD on contact, the dissolving of LSD in tap water is not appropriate. Shulgin; TIHKAL

How do these impurities change the optimum course of action of LSD and the experience it creates? One of the theories is that, because d-LSD-25 is like a key (its outer electron shell has a specific shape), it fits into a number of tiny locks called "receptor sites." These are located somewhere in the brain - nobody is sure where, but one theory suggests that they might be in the brain stem. It is known, however, that these receptor sites interact only with extremely specific molecular configurations.

The various ergot compounds, cycloalkamides of LSD and lumi-LSD plug into the same receptor sites as LSD does. But these compounds evidently don't turn the lock in the smooth, clean manner of LSD. Many of these compounds have effects similar to symptoms of ergot poisoning - the St. Anthony's Fire of the Middle Ages. These symptoms include inflamed joints, headaches, nausea, and hot and cold flashes.
Hi
Isomers of LSD are another possible contaminant and indeed are reported present by the drug analysis groups. There are four possible isomers of LSD, but only the d-lysergic acid diethyl amide form is active. The other rotation forms - l-lysergic acid diethyl amide, d and l iso-lysergic acid diethyl amide (contrary to recent reports!) - are inactive. they have no pharmacological role, except possibly as a catalyst for some latent effect of LSD, or to block the action of LSD at the receptor site.

If a contaminated batch of diethyl amine is used in the manufacturing process, or if the chemist purposely decides to make them, LSD homologues might be present in the final crystal. Molecules similar to LSD in structure but with some addition, subtraction or rearrangement of action, homologues plug into the same keyhole that LSD does.

Some of these homologues have profound effects that vary in course of action and potency. For example, the strongest of he homologues, ALD-52, has 91 percent the potency of LSD and is said to have a slightly different effect upon the mind (there is some dispute about this).

However, as Albert Hofmann puts it in "Drugs Affecting the Central Nervous System": LSD has the highest and most specific effect and may therefore be considered as the genuine prototype of psychotomimetic compounds."

Thus, all impurities found in LSD are like imperfect keys. Such substances as ergot alkaloids, cycloalkamides and other lysergic acid derivatives, and LSD homologues and lumi-LSD are drugs that might open the door part way. But only pure LSD opens the doors of perception all the way.

In addition to manufactured impurities, impurities can also arise from decomposition of LSD. Dr. Albert Hofmann points out in his paper "The Chemistry of LSD": "The free base as well as the tartrate of d-lysergic acid diethyl amide, like all lysergic acid derivatives, is very sensitive to light and oxidizing agents. All preparations must be stored carefully, protected from light and from oxygen of the air, to prevent them from being destroyed within a short time."

Even if, by some chance, an underground batch were made pure, it would turn to bunk in time, especially if put in conventional underground packaging (blotter or windowpane) that does not protect it from light or air. Pharmaceutical LSD is stored in vacuum vials in nitrogen gas. A pure, viable form of black-market LSD should find its way to the consumer in a tablet coated with pure, inert buffering material or in a vacuum vial, but this expensive packaging is certainly not reconcilable with dealing for profit.

Why is it that most of he underground LSD in the United States is made wrong? There are several other possible explanations. One chemist, for instance, told me that it was "because all the pros are out of the field." That is to say, most underground chemists, whether motivated by altruism or greed, are incompetent to manufacture pharmaceutical-grade chemicals. https://www.erowid.org/c.../lsd/lsd_writings1.shtml

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is there a simple way to "clean"my"bad"acid ?