From my understanding, the mind cannot sustain certain forms of alternative conscious experience because the brain needs to maintain homeostasis using strategies such as upregulating/downregulating of neurotransmitter reception.

A critical example of this, I think, is the tolerance exponential build-up following repeated administration of serotoninergic phenetylamines such as mescaline.

If we were able to prevent the brain from instilling homeostasis by sensitization of the right system of neurons (5HT2A serotonin receptors in the previous case), could we then sustain no-tolerance build-up and then humans would be able to live in a alternative state of consciousness forever/as-long-as-they-need-or-supply-last/until-neuroplasticity-enforces-permanent-perceptual-enhancement ?

Isn't this moar or less what we are seeing happen at the endogenous level with long-term disciplined meditative/yogic practices?

The idea that "the mind cannot sustain certain forms of alternative conscious experience because the brain needs to maintain homeostasis using strategies such as upregulating/downregulating of neurotransmitter reception"is incredibly enlightening if true!

That explains everything and actually synthesizes all of my knowledge of nootropics, biohacking, cannabis potentiation of nootropics, the psilocybin transcendental experience in which time breaks like glass - because these are all examples of neurochemically induced extraordinary states of perception. For the same reason that a lot of people will use piracetam successfully for six months to two years and then for the drug to become irreversibly ineffective. You powered on, as a result of tinkering with brain chemistry through these compounds for a time, certain lenses of perspective and saw through them for awhile, for as long as your brain took to regain homeostasis, or otherwise known as normality.

The mind is always seeking a normal frame of consciousness.
The brain is always seeking to regain it's own internal neurochemical balances after having been disturbed.
This means the principle of balance is also the principle of homeostasis, or normality, like a "base reality".
This applies both physiologically and psychologically.

For me psychologically:

• DMT : Er, still processing.

• Cannabis : It depends on strain and dose but generally a morning smoke will set my perspective right for the day.

• Psilocybin : 5 g doses. Usually six months to a year to process that. Time moves so fast and yet not at all.

and name any other drug and i bet it applies.

Physiologically, the same idea applies to the brain - always seeking balance.

Could we then sustain no-tolerance build-up and then humans would be able to live in a alternative state of consciousness forever/as-long-as-they-need-or-supply-last/until-neuroplasticity-enforces-permanent-perceptual-enhancement ?

No. You would eventually forget your there in that frame of mind and go searching for another frame of mind in order to know the first one. Because you can't know yourself except through others. Others are Yourself. You in your own body are only a mirror of others. Others too.

Existence is contrast. Contrast is writ in the nature of nature herself. Difference is fundamental to knowing back and front, myself and yourself. God knows himself only through this contrast, and never otherwise, manifesting himself as everything in being. He never knows himself otherwise, because striving after constrastlessness would be like the eye trying to see itself, or a fire trying to burn itself, or the void trying to make itself more void.

Just try to do this on 5 grams of psilocybin. Try as hard as you can to see who it is who is trying to see himself.

Anyway, all enhancements in time, once novel, always become boring and normal eventually because we've successfully integrated them into our lives, making previously novel enhancements unconscious to those seeking the next great novel enhancement. It just continues on and on in a circle - it never ends.