Hi psyduckmonkey,
how is it going?

what do you mean by ?

The strongest THC percentage in the flower of cannabis, that i found was around 32%.
Highest THC Strains

I find the video lacks in accuracy, the title says "Intravenous THC & CBD Experiment", but she talks about a mixture of THC and Cannabinoid. She probably means Cannabidiol.

In personally found, as i read more about the pharmacologial aspects of cannabinoids, and substances in general, that it doesn't seem to do justice to say substance X does this and substance Y does that. Because the individual interactions, from my point of view, often seem to be unpredictable.

A few links that you might find interesting.
CBD Misconceptions
Brain Science & the Endocannabinoid System
Flavonoids, Terpenes and Terpenoids

Hmm, as i'm reading my post, i fear coming across like a smartass, but i just wanted to share some thoughts.

FromMeToYou

I wanted to edit my post, but ended up quoting myself...
If a moderator reads this, please delete this post.

Thanks

http://www.iflscience.com/healt...s-dangers-skunk-cannabis
http://www.drugandalcoholdepend...%2810%2900336-4/abstract
Further abstracts can be dug up via Google Scholar on demand.


I did say 10-40% to give a sense of magnitude, not as an accurate measurement. Actually, with 32%, I wasn't all that much off.


It's a popular newscast, not a scientific article. It's quite revealing, regardless of slips of the tongue. Should we discuss grammar and typos next?


Well, there are general lines you can draw up even in terms of subjective experience... I've had a sense of "something missing" when smoking "modern" high-THC cannabis well before I've come across these researches, just comparing it to the weak, "crappy" regular marijuana I used to have 15 years ago. It just made me feel stupid, and none of the "nice" stuff - so I'm inclined to say that people who have only ever smoked high-potency, low-CBD cannabis have no idea what real cannabis should feel like.

Also, if you check the abstracts I've posted above, it's about cold objective biology, not just subjective experiences.


Where did I commit any of these "sins"? I wasn't demonizing THC, I was making a case for the regular, original ratio of the two. (That is, regular old low-potency cannabis, or strains specifically bred as high CBD.)

oh wow. thats amazing. recently ive been having crazy bad mind trips smoking cannabis in the morning before i eat. if i eat first im fine. but if not i trip out and ill throw up and itll feel like a bad lsa trip without the visuals! ive gotten psychedelic effects from eating cannabis before but thats it

The paper I attached in the thread below is definitely relevant here for anybody interested.

"Piomelli & Russo 2016_The Cannabis sativa Versus Cannabis indica Debate_An Interview with Ethan Russo MD".

https://www.dmt-nexus.me...aspx?g=posts&t=68655

It seems that the many other terpenoids present in cannabis are largely overlooked in comparison to the few with which we're all familiar, like THC and CBD. It also seems like some of these terpeoinds could indeed impart their own psychoactive effects, and I've heard another advantage of vapourising compared to smoking is that much more of these terpenoids are preserved as opposed to being destroyed via combustion, and that they have beneficial lung-soothing properties.

A few relevant excerpts from the paper:

CCR: Some users describe the psychoactive effects of Cannabis indica and sativa as being distinctive, even opposite. But are they really? Beyond self-reports from users, is there any hard evidence for pharmacologically different species of Cannabis?

Dr. Russo: There are biochemically distinct strains of Cannabis, but the sativa/indica distinction as commonly applied in the lay literature is total nonsense and an exercise in futility. One cannot in any way currently guess the biochemical content of a given Cannabis plant based on its height, branching, or leaf morphology. The degree of interbreeding/hybridization is such that only a biochemical assay tells a potential consumer or scientist what is really in the plant. It is essential that future commerce
allows complete and accurate cannabinoid and terpenoid profiles to be available.

CCR: Sativa is often described as being uplifting and energetic, whereas indica as being relaxing and calming. Can you speculate on what could be the basis for these perceived differences?

Dr. Russo: We would all prefer simple nostrums to explain complex systems, but this is futile and even potentially dangerous in the context of a psychoactive drug such as Cannabis. Once again, it is necessary to quantify the biochemical components of a given Cannabis strain and correlate these with the observed effects in real patients. Beyond the increasing number of CBD predominant strains in recent years, almost all Cannabis on the market has been from high-THC strains. The differences in observed effects in Cannabis are then due to their terpenoid content, which is rarely assayed, let alone reported to potential consumers. The sedation of the so-called indica strains is falsely attributed to CBD content when, in fact, CBD is stimulating in low and moderate doses! Rather, sedation in most common Cannabis strains is attributable to their myrcene content, a monoterpene with a strongly sedative couch-lock effect that resembles a narcotic. In contrast, a high limonene content (common to citrus peels) will be uplifting on mood, while the presence of the relatively rare terpene in Cannabis, alpha-pinene, can effectively reduce or eliminate the short-term memory impairment classically induced by THC.

This suggests there is a clear incentive for 'fine-tuning' cannabis with carefully selected blends of essential oils. And also that aromatherapy has more than a grain of truth to it.

Hello Everyone!! haha I'm so glad this topic is taking off like it is!!

Like posted earlier, I am getting pure Myrcene on friday (around then) and When I get some bud im going to be doing a few tests... I was thinking, since Myrcene is initially what decides if your strain is Indica or Sativa dominant, Should I do a test like this:
Say my strains on average 10-25% THC, if I weigh out 1/10th of a gram that should have somewhere around 10-25mg of THC. So I take tripple that of Myrcene to give Indica dominant effects to the bud. I'm considering using the Myrcene in my vape and just measuring out how much im taking in in relation to THC and see how the different ratios effect the experience and if it makes normal or sub-par Cannabis strong enough for me to trip (I believe my brain chemistry is a bit off and I am able to trip off of weed easier than most since my previous psychedelic use).
Also. Myrcene is a very LARGE part of the couch lock part of cannabis. Not just CBD. As far as nuro-tox(icity or whatever) goes... Cannabis is one of the safest substances known to man is it not? The fact that CBD is benificial has nothing to do with its nuro-tox level. At least to my knowledge. In all honesty, just about every terpenes and cannabonoid in cannabis has benifits of its own. Myrcene by itself can release opiates in the brain and provides the benifits to cannabis for muscle relaxation, pain killing, insomnia and other things. If one were to take all "phycoactive" (meaning that it produces some kind of wanted effect at least in conjunction with THC) terpenes with pure THC in a pre-determined ratio, it would pretty much be like smoking normal weed (prolly more potent seeing as the chemicals being taken in are in pure form and not binded to plant material).

And sorry for the spelling errors. To tired to fix em rn.

CBD doesn't contribute to the couch-lock effect. CBN does.


It is. That said, based on the facts I know, I'd posit that it's CBD that makes it so. Also don't tell me you haven't ever seen "potheads" who managed to smoke their brains flat. Just as with alcohol, prolonged addiction and regular use does have a negative impact.


Yes it does. THC seems to exhibit (low) neurotoxicity that a mixture of THC and CBD combined do not. Think of it as lubrication in your car engine. You have gas (THC) to turn the engine, and lubricant (CBD) to make sure it doesn't degrade.


Indeed, cannabis is a highly complex plant that cannot be boiled down to one or two compounds. (Which is why I prefer low potency cannabis, as smoking more of the whole plant for the same amount of THC gives you a more complete experience.)

Sorry for my confusion PsyDuckmonkey!! haha I though nero-toxicity was what the medical term for Overdose or somethin (I've been quite fucked up lately). And yeah... Ive seen people who started smoking way to young and kept it up for way to long and their pretty stupid... Although part of it may be the fact that pot make you want to sleep instead of learn (at least in my past experience). Very interesting that you prefer the lower potency cannabis. I know typically on the black market its really cheap and will still get you pretty fucked up (Expecially Brownies with it!!).

Neurotoxicity means what it says. Certain psychedelic compounds are harmful to the nervous system at a cellular level.

For example it's pretty much proven that chronic MDMA use damages the serotonine system. There is some evidence that chronic THC use (without an appropriate amount of CBD as a neuroprotective) may damage white matter (long axons and glia mass), and cause structural deterioration in the inner brain.

Update on the Myrcene. I got a bottle of 100% tday and mixed a few drops with some of my vape fluid. After a few hits (allready under the influence of cannabis) I am pretty messed up. I have 4mg Nicotine in my juice so that may account for some of what im feeling.

With how much vape fluid? Myrcene is present in Indica in truly minute amounts, you likely overdosed it like crazy.

Ehhhhh yeahhhh prolly so... I feel fine tho. Actually it will get me high on its own. I used less than a 1 to 5 ratio in my vape fluid. "Supposedly" essential oils wreck atomizers. But mine has been puffing away no problem. I did some research on Myrcene before I tried it to see if it is used in medical sciences. It is mainly for treatment of pain and insomnia. It releases natural opiates within the brain. I though seeing as how someone can eat a good amount of mangoes (which I believe have like 40% Myrcene) and not die or anything, it would be fine to vape a substantial amount and not subdue to harm. Also I know people who have eaten and smoked a WHOLE WHOLE bunch of weed and not had anything to horrible happen (aside from THC related things). I give it a thumbs up as long as your safe about it and do some homework on it. Tastes like mangoes with a pungent earthy weed like but not to weed like taste and odor.

Still 20% sounds like a LOT... Indica has maybe like 2% of it. and you eat mangoes, not smoke them, haha. But if you're okay then it's cool I guess.