DMT-Nexus member
Posts: 21 Joined: 06-Dec-2014 Last visit: 25-Oct-2016 Location: Colombia
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Nexus is really great, i haven't know about cyclodextrin in the increasing bioavailabilty of sublingual Salvinorin A. It's a really interesting research topic we must go deep. Has anyone trying by itself? Salvinorin alpha crystals: HereAre you from Colombia, South America (or not) and want to establish alliances to promote research in psychedelic drugs in our land? Please PM or contact me in http://www.caapi.co or caapi.sas@gmail.com
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DMT-Nexus member
Posts: 3335 Joined: 04-Mar-2010 Last visit: 08-Mar-2024
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caapi.colombia wrote:Nexus is really great, i haven't know about cyclodextrin in the increasing bioavailabilty of sublingual Salvinorin A. It's a really interesting research topic we must go deep.
Has anyone trying by itself? I haven’t tried this, but it would be great if there was a way to make Salvinorin A readily absorbable. I’ve tried using it sublingually, in chewing gum, insufflated, and none of these modes of administration work at all, even with fairly large doses of 10+ mg. Tangentially related: Take a look at the Salvinorin crystals in the attached photo. They were recrystallized from a mix of acetone and water (I think I have a thread about this somewhere.) gibran2 attached the following image(s): crystal.jpg (126kb) downloaded 148 time(s).gibran2 is a fictional character. Any resemblance to anyone living or dead is purely coincidental.
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DMT-Nexus member
Posts: 12340 Joined: 12-Nov-2008 Last visit: 02-Apr-2023 Location: pacific
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Have you tried simply quiding fresh or re-hydrated leaf? Long live the unwoke.
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DMT-Nexus member
Posts: 21 Joined: 06-Dec-2014 Last visit: 25-Oct-2016 Location: Colombia
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Lovely crystals gribran2. I had read somewhere about the possibility of fresh leaves to be more active than dry leaves (taken sublingually), maybe because there are some others molecules that interact with them and increase the sublingual bioavailability. Salvinorin alpha crystals: HereAre you from Colombia, South America (or not) and want to establish alliances to promote research in psychedelic drugs in our land? Please PM or contact me in http://www.caapi.co or caapi.sas@gmail.com
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DMT-Nexus member
Posts: 3335 Joined: 04-Mar-2010 Last visit: 08-Mar-2024
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I’ve tried quidding fresh leaves a few times, but have had limited success. I probably didn’t use enough leaves. I agree that there is something about leaves – either chemical or physical – that increases bioavailability. If I didn’t prefer the smoked route of administration, I would probably be experimenting more with quidding. gibran2 is a fictional character. Any resemblance to anyone living or dead is purely coincidental.
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DMT-Nexus member
Posts: 1045 Joined: 12-Mar-2010 Last visit: 11-Jun-2024 Location: Urf
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RhythmSpring wrote:Is it possible to put it on blotter for sublingual use? RhythmSpring wrote:Agh, I'm not learned enough to understand most of this. Can you say yes or no, or at least explain in simpler terms? Anyone? Salvia on blotter paper? From the unspoken Grows the once broken
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DMT-Nexus member
Posts: 3335 Joined: 04-Mar-2010 Last visit: 08-Mar-2024
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RhythmSpring wrote:RhythmSpring wrote:Is it possible to put it on blotter for sublingual use? RhythmSpring wrote:Agh, I'm not learned enough to understand most of this. Can you say yes or no, or at least explain in simpler terms? Anyone? Salvia on blotter paper? I've never tried this, but based on my various sublingual experiments, I'm quite sure it would not work. gibran2 is a fictional character. Any resemblance to anyone living or dead is purely coincidental.
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DMT-Nexus member
Posts: 21 Joined: 06-Dec-2014 Last visit: 25-Oct-2016 Location: Colombia
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I agree, the problem seems to be the fact that Salvinorin A by itself is poorly absorved sublingually, more than the way of administration (blotter, leaves, alcohol, etc.). Im gonna take a look to the cyclodextrin and maybe try it. Salvinorin alpha crystals: HereAre you from Colombia, South America (or not) and want to establish alliances to promote research in psychedelic drugs in our land? Please PM or contact me in http://www.caapi.co or caapi.sas@gmail.com
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DMT-Nexus member
Posts: 303 Joined: 07-Aug-2013 Last visit: 10-Jul-2015 Location: NonLocal
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There is some good anecdotal evidence out ''there'' that sublingual or buccal salvinorin dissolved in dmso is a very effective method of administration. I've had some pure dmso liquid for a few months now, just haven't found the correct time to test it out. I will report back when I do though. I am very interested to find out!
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