DMT-Nexus member
Posts: 20 Joined: 11-Apr-2015 Last visit: 03-Aug-2018 Location: scotland, uk
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I have been on olanzapine fora couple of weeks and would like to know if they might conflict
With mexaca and how so gbthanks po
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DMT-Nexus member
Posts: 975 Joined: 24-Jan-2015 Last visit: 17-Aug-2025
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Yes, you will feel less potency but you might still feel it if you take 5-10grams of mexicana but people report it on shroomery as being not as vibrant and a bit dull. Try it out or just wait a week to stop olanzapine. I know that stuff really made me sleep heavy and inhibited my thought processes (stupified me) so I eventually stopped as it wasn't worth the cost to my intellect. Are you taking it for psychosis? have truffles amplified your pychosis in the past? I once took olanzapine after my first try of MHRB ayahuasca because I was scared and wanted to void the trip, needless to say it needs a couple of days to start working. so I threw it up with the finger in throat.
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Posts: 1716 Joined: 23-Apr-2012 Last visit: 23-Jan-2017
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Aya_4_life wrote:I have been on olanzapine fora couple of weeks and would like to know if they might conflict
With mexaca and how so gbthanks po There's a competitive action at the 5HT2A/C receptors. You might dose the psi high to feel effects but I won't recommend it. Half life of Ola is 33hs, so it takes at least 66h after the last intake to feel diminished effects and more than 132-198h before it's really out of your system. Have you thought about set, setting and dose? Being on antipsychotics is not the best idea while tripping. You know it's not a party drug and you certainly get the Ola for a reason, right? Quote:Olanzapine is an atypical antipsychotic agent of the thiobenzodiazepine class. It blocks multiple neurotransmitter receptors including dopaminergic at D1, D2, D3, D4 brain receptors, serotonergic at 5-HT2a, 5-HT2c, 5-HT3, 5-HT6 receptors, catecholamines at alpha1 adrenergic receptors, acetylcholine at muscarinic receptors, and histamine at H1 receptors. Olanzapine has five times the affinity for 5-HT2 receptors than D2 receptors and has been used to treat schizophrenia and delirium. Olanzapine's activity at multiple receptors, particularly at the D2, 5-HT2c, and 5-HT3 receptors which appear to be involved in nausea and emesis, has prompted its use in the treatment of nausea and vomiting refractory to standard antiemetics. https://www.ncbi.nlm.nih.../24157985?dopt=Abstract
Quote:Psilocybin is rapidly dephosphorylated in the body to psilocin, which is a partial agonist for several serotonergic receptors. Psilocin has a high affinity for the 5-HT2A serotonin receptor in the brain, where it mimics the effects of serotonin (5-hydroxytryptamine, or 5-HT). Psilocin binds less tightly to other serotonergic receptors 5-HT1A, 5-HT1D, and 5-HT2C.[1] Serotonin receptors are located in numerous parts of the brain, including the cerebral cortex, and are involved in a wide range of functions, including regulation of mood and motivation.[82] The psychotomimetic (psychosis-mimicking) effects of psilocin can be blocked in a dose-dependent fashion by the 5-HT2A antagonist drugs ketanserin and risperidone.[83] Although the 5-HT2A receptor is responsible for most of the effects of psilocin, various lines of evidence have shown that interactions with non-5-HT2A receptors also contribute to the subjective and behavioral effects of the drug.[84][nb 3] https://en.wikipedia.org...Psilocybin#Pharmacology
Quote:After oral administration to healthy subjects, the mean terminal elimination half-life was 33 hours (21 to 54 hours for 5th to 95th percentile) and the mean olanzapine plasma clearance was 26L/hr (12 to 47L/hr for the 5th to 95th percentile). Olanzapine pharmacokinetics varied on the basis of smoking status, gender and age. In female versus male subjects, the mean elimination half-life was somewhat prolonged (36.7hr vs 32.3hr) and the clearance was reduced (18.9L/hr vs 27.3L/hr). However, olanzapine (5-20mg) demonstrated a comparable safety profile in female (n = 467) as in male patients (n = 869). Smoking induces the CYP1A2 metabolism of olanzapine. Therefore, in smokers the clearance of olanzapine is higher, on average, than the clearance in non-smokers. https://www.ebs.tga.gov....p;id=CP-2011-PI-02375-3
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DMT-Nexus member
Posts: 20 Joined: 11-Apr-2015 Last visit: 03-Aug-2018 Location: scotland, uk
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Thanks for the advice farhomlessness might just eat the full 10 g out the 15g box , its bipolar dissotrderr im getting treated for .
and thanks ufosrahlein , for the response but I dont intend on using it as a party drug, I use tryptamines In general to open my eyes so to speak, or lift the vale as strassman says .
Na ma ste
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DMT-Nexus member
Posts: 20 Joined: 11-Apr-2015 Last visit: 03-Aug-2018 Location: scotland, uk
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Hey, my meds have been changed to respiridone, kinda worry this wall dampen my next trip to the machine elves so I may just fast for acouple of days meds too, that way I knw my trip is being influenced by other drugs or adulterants in my body at the time.
Of course set and setting comes into play, got that bit worked out just need to clarify before my next psilo-huasca trip. I thinkni may do the full 15g of mexixana
truffles along with some caapi vine. As I preffer the depth shrooms give during my trips wi maoi present.
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