As far as I know, DMT can't cause serotonin syndrome. MAOIs in conjunction with other things however can. I have experienced slight twitching/shaking on DMT but not usually enough to upset me. Weed on the other hand can make me twitch really badly sometimes, so much so that it scares me. I don't think it is too much to worry about.

I'm not a doctor and don't know any other diagnosis matching the symptoms better. I know it's not the same condition, and I didn't claim that either, but based on many symptoms, it seems close.

Some people always look for psychological explanations and thats fine, but the obvious physical mechanisms resulting from flooding our brains with serotonin agonists can't be ignored...


No, but LSD, 5-MeO-DIPT does (The Serotonin Syndrome (Boyer, 2005) )

No serotonin receptor subtype is single responsible, but evidence points out agonism of 5-HT2A receptors contributing substantially, and thats were DMT comes in to the picture, just like most other psychedelics it's a 5-HT2A agonist, but I think an important factor involved in administration of the drug is significant to explain why we don't see this with oral Ayahuasca. Smoking DMT introduce most of the drug to our brains in a minute. It's like a tsunami...

Well, that's just my theory. I would like to see some arguments based on pharmacology rather than psychology to disapprove it

@brokeneye
Great topic!!!
Ive had that strange experience of uncontrollable twitching... Last summer I took LSD and on the comedown in the AM smoked 3 large hits of really good and very hardcore spice. Just as I had inhaled the last toke, my right arm started to hopp so vividly I in a not yet worried state, passed the pipe to my friend sitting beside me on a hill in the forest. I laughed, I saw that what was happening was something so entirely new to me, but the next moment I was scared, really for the first time ever on psychedelics. The arm did not stop behaving weird, it was a hammeringlike movement, repetedly doing the same movement totally out of my control. At this time my friend put his arm around me, and said in a low nice tone that everything was allright... After this moment I think that I remember, that my trip in hyperspace was over and my arm was now silent again. I haven´t done DMT since, but in 2 weeks or so I should have a new batch to work with. I´ve been pondering on whataafack IT was that happened to me, so really great you sought me up! Thanx to you for bringing this up.

"Nothing lasts, but nothing is lost"

Most psychedelics are stimulating in some sense. Tryptamines effect serotonin and serotonin effects anxiety. That's why we use Serotonin reuptake inhibitors for anxiety and depression. DMT, Psilocybin and LSD and MDMA all cause this twitching sensation normally. It gets weird sometimes. When I smoke DMT I stretch and make strange sounds like a have a twitch. Obviously pay attention to how your body is reacting but don't over analyze it because you'll freak yourself out.

I get huge rushes of euphoria and "electrical" signal from DMT, very very similar to MDMA. That was actually the first the I noticed about DMT. It feels similar to rolling and as you up the dose it starts to feel like hippie flipping on shrooms and mdma. Just pure energy and color. Less "mind f**k" as LSD but plenty of the energy that either leads to euphoria or anxiety depending on how you handle said energy.

Glad this was brought up, I used to experience this on high doses of mushrooms quite often and still get it on weed sometimes but I've never had it on DMT yet. Right before the first time I experienced ego loss on shrooms it got so bad I thought I was seizing which was absolutely terifying, and the fear got a lot worse when I actually "died". IME fighting the experience has at least something to do with, just let go and you'll be a lot more comfortable.