the partition coefficient of simple tryptamines is close to that of diethyl ether, but they're also similar to toluene and dcm. the latter is choice, because it's volatile, but nonflammable.

Thanks for saying, I already mentioned this to him (ektor) elsewhere.

To expand, and personify:

The DCM fumes won't burn your house down and you don't have to call the bomb squad when your solvent has exceeded it's use by date

the toxicity of chloroform and dcm is often overstated. yes it's a mutagen, but you'd need to handle it for several decades before you'd even get anything resembling a wart (the same applies to handling benzene, toluene, and xylene).

The benefit of not running the risk of starting a fire is worth it, imo.

I strongly favor extracting with TCM and solvent swapping to heptane.

I always used diethyl ether because it is cheap, extremely volatile and has a low toxicity. I know the danger of explosive peroxide or ether's natural high flammability thats why I always evaporated it in an open space.

Naphta is hard to find here and if you ask for limonene they say: "lemon-what???" besides ether I can find Zippo lighter fluid, is this ok for a/b with freeze precipitation?

I know what you mean brother!! we used to inhale ether like crazy when teen ager out of chemistry lab!!!
It was fun

Thanks fo the fast responses people, you astonish me

the actual effect of 'ionic strength' in these systems is vastly overstated.

The effect it has on partition coefficient is completely negligible, especially in the case that we are talking about naphtha, which is about as non polar as it gets. Even in the case of solvents like ether and CH2Cl2, where these solvents are actually somewhat soluble in aqueous, the effect is still negligible since we perform 2 or 3 pulls instead of just one.

The effect it has on DMT freebase solubility is equally unimportant.

The only time you use the effect on the partition coefficient is for washing wet organic solvent, washing CH2cl2 or ether with saturated NaCl will suck out any of the remaining water.

The only tangible effect ionic strength has is in breaking up emulsions, micelles. That's the only place solvent is going to be trapped and considerable yield might be lost. And even THAT has more to do with the fact you are increasing the density of the aqueous layer by adding salt. And that is a perfectly good reason to use salt, I'm not arguing against it's use. In my experience though some emulsions have only been broken with excess NaOH

So please, just stop talking about ionic strength. I mean, its great to learn about all of these equilibria and understand why they are happening and how to manipulate them... But Also it is important to at the same time understand the degrees in which these equilibrium are changing... some of them change by factors of 0.0000000000001%, while others shift exponentially...