Good day Nexus, I am absolutely enthralled with micro dosing! It is a great way to explore expansive thought processes while continuing on with a completely a busy/productive sort of day. I also feel it is much less taxing way to introduce compounds to our body and mind. Conditioning the mind and reducing the chances of a traumatic first time deep end dive. Micro dosing is most commonly referred to with the use of LSD, but I like to take that concept to almost any substance, including plant entheogens. Essentially I interpret micro dosing as another way of saying 'supplementing'. I'm curious to see what others experiences and thoughts are on micro dosing, or thoughts on how it can be beneficial or even contradictions. Also, opinions on when it moves from 'micro dose' to 'low dose' territory? Not too far apart, but you can feel the difference for sure. Listening to one's body is obviously crucial in this case, and measurements/increments may need to be a more precise.

so if you're going to micrdose dmt wouldn't you have to dose enough maoi to make sure the dmt microdose takes hold?

Micro dosing certainly is an art, and can be implemented with various benefits and cautions. I encourage your deep interest and curiosity. It all depends to which the substance is of interest as all substances have different dosage levels. I see MD as supplementing for the spirit. Prolonged MD may have depleting effects, but is safe otherwise.

LSD-25 is psychedelically active within 100-200 micrograms (afaik) and would need extreme measurement beforehand. Yes, DMT would need MAOI to release benefits. Although, I'm not sure of anyone trying this. Scaling 1mg of DMT and 0.1g of rue would probably be efficient without ascending yourself and possibly benefiting for MD.

I would be careful microdosing -- there was a study (it's kicking around the Magic Mushrooms subforum I think) that showed that chronic exposure to low doses of psilocybin caused cardiac abnormalities. The proposed mechanism was that agonism of the 5-HT2B receptor had mildly cardiotoxic effects (which has been verified with other agonists).

LSD's binding profile to 5-HTRs is similar, so I would worry about doing damage to your heart.

Blessings
~ND

great call! thanks for bringing this up. It is important even with micro dosing to give a decent few days at the least for a break in between.

this is the method I will be using when I do my study in January, I'm quite interested in its effect long term and short term.

Thank you for the words of encouragement That's true, great input- substance and dosage ratios are important research points to have done preemptively. Intent is definitely still relevent, possibly as well as set and setting to a certain extent I Imagine, and maybe that again depending on the substance more or less. Microdosing oral DMT is an interesting concept I could also imagine it could be great for facilitating mental aquisitions, perhaps also for good for guided meditations or perhaps even certain light exercise routines such as yoga or methodical martial arts. Perhaps best without getting to hectic or strenuous about it just for safety purposes. I'm enjoying the comments coming in on here about this, thank you for the input.

Awesome, If you don't mind or think of it in the future do please post back later and let us know how it went!

" Scaling 1mg of DMT and 0.1g of rue would probably be efficient without ascending yourself and possibly benefiting for MD. "

You would still have to take 3 G of P.Harmala for example because its the dose used to supress the MAO action in your gut .

That makes sense. I've never microdosed these two before so my experience lacks, but you make a fundamental point that more MAOI support is needed to activate the amount of tryptamine, or otherwise material used to feel (if any) MD effect.

Perhaps I'm laboring under misconceptions, but i think my idea of microdosing is different than what is being described. When i experimented with it, i had access to a large amount of ps. cyanescens harvested wild locally. I would dose a stem, or a cap or so on a weekly basis. I did not do this to achieve any psychedelic effect, but rather to observe whether there was any mood modulation. I would not try top dose enough to feel ANY psychedelic effect. Due to variations in potency and lack of weighing, occasionally, a little distortion was achieved but was accidental.

Apparently, due to its seratonergic action, psilocybin has some mood stabilisation and anti depressant qualities. I definitely noticed improvement in both areas , far more so and without the debilitating side effects i suffer from SSRIs or mood stabilizers. As a long term sufferer of severe depression and PTSD, this technique was a god send.

Hopefully one day, i and others will be able to access this medicine legally. The last couple years have been bust for me as far as mycovenatorial success goes. However, i just sourced locally grow kits for cubes and as soon as i can rent the space to do so, plan to grow a supply for myself. I would very much like to continue this therapeutic route. The close to a year that i worked with it was one of the most productive of my latter years and i would like to see where my life could go and what i could achieve if it weren't for paralyzing bouts with depression.

Interesting.. I have also had success with very low (below threshold) experiences, once or twice a week depending what psychedelic substance that is. With salvia, I was able to function while feeling more aware, open and some improvement with emotions. This plant already has been shown to enhance feelings, stability etc, after being used spiritually in higher doses following strong, positive afterglow effects.

Tryptamine 4-Aco-DMT at very low dosages seems to enhance energy, well-being and communication. Was able to function with all tasks being done.

LSA also has potential for improving well-being, mood and thoughts. Did only once a week with 5 or 10 seeds. The mental effects were apparent, but also was my stomach couldn't accept the seeds anymore after a few weeks. Extracts would be more efficient.

Very small hits of cannabis are stimulating ime, and enhance mood, thought and interest. Tobacco in very small dosages is anxiety reducing imo, with overall relaxed feeling. Kava also has some calming, medicinal effects below threshold.

Overall, many different plants have subtle effects that have subtle improvements. Especially with a very good diet, activities etc. Long term effects can be maintained, but should never be chronic or continued in that it may upset an organ system. Once a week should be okay with every caution outlined.

Plant medicine is all i rely on these days. While i could use an asthma inhaler, the majority of my ails are, well, in my head lol. I use cannabis near daily for anxiolytic effects, and i spoke to my use of psilocybin. To go out and pull my medicine from the earth, rather than rely on the pharmaind, is where its at, afaic.

Salvia interests me. My one real exp with it left me feeling mind raped immediately after, but i did notice some positive long term effects. I'd like to explore it more, but as with the mushroom cultivation, need a safe place to do so.

Things on the psychedelic front have been a little difficult for me as late. My only real connection with the community is through here (despite living in a place that I'm sure has a thriving local one, but like gregarious cyan clusters this season past, eludes me. ) My trip partner moved and my best friend, while not a tripper but who would sit for me, passed on last summer.

LSA also sounds like it may possibly be a more accessible route, as long as once again, safe extraction environs are located and secured.

SWIM uses spice about daily, and often doses a bit below breakthrough (of course sometimes he *accidently* gets completely launched into hyperspace even when that's not the intended goal). I do this early in the morning. I get up at 5am, go to the gym for 2 hours to exhaust my body, then come home, meditate for 30-60 minutes, dose DMT (vapors, nor oral), and then spend another 20-30 minutes mediating afterwords.

I think of this as "DMT Microdosing." I realize that it's not really "microdosing" but it strikes me as the best way to do so with inhaled spice.

And to those of you above who brought up the cardio effects of microdosing mushrooms, thank you! That's very interesting information and I'm going to look into it more thoroughly when I get back from work tonight.

Love and peace y'allz!

I can't speak to regular DMT dosing, honestly I feel its in a class all its own, at sub-or just above threshold doses, it leaves me feeling...disturbed is really the only way i can put it. It's all or nothing with me and spice. I like to access hyper space a few times a year just to blow out the cobwebs, so to speak. To remind me

Yeah, so IDK about that. Tryptamine micro dosing as a regimen needs be looked at,and like all other clinical aspects of psychedelic medicine, to be defined.

It seems we're the vanguard of that research here, glad the nexus is here .