Excellent thread. I am 67 years old and beginning to explore the world of psychoactives after many years. I do have coronary artery disease with two stents placed in 2008. Fortunately, I suffered no damage and with proper exercise, diet etc. I have no negative symptoms. I do not take any pharmaceuticals (funny, I do not like pharmaceuticals but very much like psychoactives). Thus far I have been micro dosing the substances in which I have interest including LSZ, AL_LAD, truffles, MXE, %-MEO-DMT, 5-MEO-DMT and Iboga with no problem. I intend to ramp up slowly as my purpose is inner exploration and not recreational although the pleasurable effects are welcome and much appreciated. I would like to hear from any other explorers who are carefully exploring with similar conditions.