I have jammed on my guitar on a variety of psychedelics. Different psychedelics definitely inspire differently, affecting the way I emotionally want to play differently, and also how they can differently affect my very muscle movements.

LSD has a strong electric edge to it for me a lot of the time. Lots of energy can get pent up in the body that is just itching to come out, so LSD-fueled jams can involve expending a lot of energy, sometimes even to the point of frustration in coping with "boundary dissolution" issues. I sometimes feel like even though I'm well-connected to the music, I'm always just off the mark of completely satisfying myself on an emotional level (though not always). It can make music sound watery and cavernous to me at times, and so I will often try and take advantage of this by tripping out my guitar with a bunch of delay, reverb, swelling, S/H (sampled/held) sounds, etc...to create as much of my inner atmosphere in my outer musical display.

When I take pharma, I use rue as my MAOi. It has a bit of an insectoid vibe to it a lot of the time, and the energies in the air can entrain my fingers quite well, and cause them to snap into place seemingly quicker than normal with good precision. Because the energy is perceived as being outside of the body, interacting with my muscles from the outside, it doesn't create the same kind of emotional frustration as LSD. Pharma really allows for a strong connection with the music, and can encourage groove.

Although DMT typically provides for a lot of inspiration to be integrated into the music after the experience, some times on the comedown during the afterglow when things are still quite psychedelic, but the "main plot" has lost its thread so-to-speak, I will pick up the guitar. On a strong afterglow with full-blown synesthesia in effect, the experience fully becomes painting with sound (though it can feel like that on the other psychs as well). Every note and motion both create and modify hyperspatial objects. The beautiful thing about it all is how attention can affect the energy so much, so that when my music synesthetically creates a hyperspatial object for me to view, as I view it and direct my attention at it, it will continue to develop and flourish, and my attention that is being split on the music is creating a feedback loop of sorts.

On one occasion, I did play guitar from start to finish just to see what would happen. It was a marvelously wonderful experience. As 4D+ entities objects began forming out of the wall I was observing, they made their way over to me, gyroscopically twisting and corkscrewing their way over to me slowly, completely cymatically entrained by by music. "Everyone" involved was quite ecstatic. It felt like I was putting on a concert of sorts for them. I did record it (as I have with many of my other psychedelic jams) and wrote about it on here somewhere I think...

I can't recall if a specific instance when I've played guitar on salvia, though I don't doubt that it has happened, but the tactile distortion and confusion are just too much to cope with during that particular experience.

With DiPT, some kinds of music were much better to play than others. Anything that was "tonal" or harmonic should be avoided. The pitch shifting makes it too wonky for anything like that, but doing more atonal and fantastical stuff is fun and exciting. Everything sounded low, metallic, hollow and with a ring modulator kind of effect on it (not like a harsh one, but a tone like that).

Mushrooms can give me quite the whimsical, gnomish vibe, and that can inspire some cutsy "magical" kinds of playing.

I've played Smash Bros Brawl shortly after smoking DMT... about 4-5 minutes after smoking to where I could sort of process my surroundings but still saw amazing fractals and visuals. It was incredible. The game looked completely different, from the characters to the stages to the attacks. The Gamecube controller is perfect, and I could still play quite well. I got second place out of our group of four people. Granted, we're not professionals or anything, but they said I wasn't too much different to play on DMT (they weren't on DMT). The fact that DMT altered the game's visuals to look even cooler and more profound, like it was a completely different videogame, was totally remarkable.

At certain doses it has been great for yoga and guitar, or walking around nature. DMT is extremely similar to mushrooms for me.