DMT-Nexus member
Posts: 393 Joined: 31-Mar-2013 Last visit: 30-Oct-2022
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They live in the gulf of mexico, and turn dark purple when exposed to oxygen. (Hm, kind of like magic mushrooms Hopefully they are overpopulated ) *ALL WAYS WITH LOVE
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DMT-Nexus member
Posts: 587 Joined: 02-May-2013 Last visit: 16-Apr-2018
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WOW!!!! I see these sponges all the time when i dive around where I live and I never knew they contained DMT/DMT analogues. Unfortunately, I don't want to harvest them because harvesting sponges is a felony where I live and do not want to risk pissing off the local marine patrol. If any nexian gets the guts to procure some sponges and extract some 5,6 Bromo DMT from these guys please let us know how it works out! I'm listening with all three of my ears. '"ALAS,"said the mouse, "the world is growing smaller every day. At the beginning it was so big that I was afraid, I kept running and running, and I was glad when at last I saw walls far away to the right and left, but these long walls have narrowed so quickly that I am in the last chamber already, and there in the corner stands the trap that I must run into." "You only need to change your direction," said the cat, and ate it up.' --Franz Kafka
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DMT-Nexus member
Posts: 459 Joined: 19-Jul-2012 Last visit: 29-Mar-2024
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I'm no chemist, but I woner if the Bromo makes the hallucinogen inactive, I only have one relative example which is 2Bromo-LSD which is not a hallucinogen but shows promise for Cluster Headache Treatment. http://en.wikipedia.org/wiki/2-Bromo-LSDCreator help me live in a way that will make my ancestors proud.
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DMT-Nexus member
Posts: 1892 Joined: 05-Oct-2010 Last visit: 02-Oct-2024
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Come on, who is going to be the first to try and smoalk a bowl of sponge? *Taps foot*. Art Van D'lay wrote:Smoalk. It. And. See.
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Homo discens
Posts: 1827 Joined: 02-Aug-2012 Last visit: 07-Aug-2020
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Muskogee Herbman wrote:I'm no chemist, but I woner if the Bromo makes the hallucinogen inactive, I only have one relative example which is 2Bromo-LSD which is not a hallucinogen but shows promise for Cluster Headache Treatment. http://en.wikipedia.org/wiki/2-Bromo-LSD Well, Bromo-DragonFLY and 2C-B are obviously both active, so a bromine atom in a compounds chemical makeup is not enough to render a compound inactive. But I'm also no chemist, so I don't know how the position of the bromine atom(s) might alter a compound's potential for activity.
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DMT-Nexus member
Posts: 459 Joined: 19-Jul-2012 Last visit: 29-Mar-2024
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Entheogenerator wrote:Well, Bromo-DragonFLY and 2C-B are obviously both active, so a bromine atom in a compounds chemical makeup is not enough to render a compound inactive. But I'm also no chemist, so I don't know how the position of the bromine atom(s) might alter a compound's potential for activity. Ah thanks I forgot about those guys have Bromo attachments Creator help me live in a way that will make my ancestors proud.
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DMT-Nexus member
Posts: 2151 Joined: 23-Nov-2012 Last visit: 07-Mar-2017
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Entheogenerator wrote:Muskogee Herbman wrote:I'm no chemist, but I woner if the Bromo makes the hallucinogen inactive, I only have one relative example which is 2Bromo-LSD which is not a hallucinogen but shows promise for Cluster Headache Treatment. http://en.wikipedia.org/wiki/2-Bromo-LSD Well, Bromo-DragonFLY and 2C-B are obviously both active, so a bromine atom in a compounds chemical makeup is not enough to render a compound inactive. But I'm also no chemist, so I don't know how the position of the bromine atom(s) might alter a compound's potential for activity. Given that DMT is active when a variety of other functional groups are stuck on the 5 position, I would expect 5-Br-DMT, although depending on how DMT binds to 5-HT receptors, the size of the Br group might cause steric strain. Does anyone know exactly what the active site on the 5-HT2AR (or any other 5-HTRs) looks like? Nichols did a lot of work looking at the activity of various substituted hallucinogenic tryptamines. Here's the abstract, I'll post the full text when I have a moment to dig it up http://www.ncbi.nlm.nih.gov/pubmed/11101361"There are many paths up the same mountain."
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member for the trees
Posts: 4003 Joined: 28-Jun-2011 Last visit: 27-May-2024
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^^^ ..we have this first known bioassay report of 5-Br-DMT (p.1) , with activity, apparently about half the potency of DMT..
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DMT-Nexus member
Posts: 2151 Joined: 23-Nov-2012 Last visit: 07-Mar-2017
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nen888 wrote:^^^ ..we have this first known bioassay report of 5-Br-DMT (p.1) , with activity, apparently about half the potency of DMT.. Nice, I had thought that was looking at 5,6-Br-DMT, not just 5-Br-DMT. Where does Hamilton work that he has access to GC-MS and NMR for random samples of drugs? "There are many paths up the same mountain."
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DMT-Nexus member
Posts: 587 Joined: 02-May-2013 Last visit: 16-Apr-2018
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Does anyone on this forum have the faintest idea as to how to extract alkaloid from sponges? I found GOADS of these sponges growing all over some rocks down the street from my place and was wondering if anyone here had any experience with extracting from sea life. Should I do several freeze and thaws before hand, blend sponge prior to boiling, and what solvent should i use, etc etc? The bioassays sounded promising and colorful results from this molecule and I cannot wait to begin my journey with it! '"ALAS,"said the mouse, "the world is growing smaller every day. At the beginning it was so big that I was afraid, I kept running and running, and I was glad when at last I saw walls far away to the right and left, but these long walls have narrowed so quickly that I am in the last chamber already, and there in the corner stands the trap that I must run into." "You only need to change your direction," said the cat, and ate it up.' --Franz Kafka
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DMT-Nexus member
Posts: 2151 Joined: 23-Nov-2012 Last visit: 07-Mar-2017
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Godsmacker wrote:Does anyone on this forum have the faintest idea as to how to extract alkaloid from sponges? I found GOADS of these sponges growing all over some rocks down the street from my place and was wondering if anyone here had any experience with extracting from sea life. Should I do several freeze and thaws before hand, blend sponge prior to boiling, and what solvent should i use, etc etc? The bioassays sounded promising and colorful results from this molecule and I cannot wait to begin my journey with it! Hold your horses there. Before you start extracting from mystery sponges, you should 1) double check the identity of the sponge, and 2) make sure there's nothing toxic in the sponges in addition to the tryptamines that you might pull. In theory though, an extraction from a sponge would work like any normal extraction. Just stick them in a blender. I'm sure *everyone* would love to know what you find. If we have a reliable source for 5-Br-DMT, that could make getting the various substituats of DMT much easier. There are tons of reactions that will allow you to replace the halide with a functional group like hydroxy or methoxy. 5-MeO for the masses! "There are many paths up the same mountain."
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Boundary condition
Posts: 8617 Joined: 30-Aug-2008 Last visit: 24-Oct-2024 Location: square root of minus one
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Nathanial.Dread wrote:There are tons of reactions that will allow you to replace the halide with a functional group like hydroxy or methoxy. 5-MeO for the masses! There are not necessarily 'tons' of reactions that would a) do this without turning the indole into a tarry mess and/or b) be easily achievable by the kitchen chemist. Also, you'd better start farming and nurturing these poor critters before setting off (yet another) extinction just because some of you 'want to get high'. Try breath exercises first (it will help with the sponge diving, after all ) “There is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work." ― Jacques Bergier, quoting Fulcanelli
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analytical chemist
Posts: 7463 Joined: 21-May-2008 Last visit: 03-Mar-2024 Location: the lab
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nen888 wrote:^^^ ..we have this first known bioassay report of 5-Br-DMT (p.1) , with activity, apparently about half the potency of DMT.. interesting... are there any known Km values for this compound? "Nothing is true, everything is permitted." ~ hassan i sabbah "Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
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analytical chemist
Posts: 7463 Joined: 21-May-2008 Last visit: 03-Mar-2024 Location: the lab
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Entheogenerator wrote:Muskogee Herbman wrote:I'm no chemist, but I woner if the Bromo makes the hallucinogen inactive, I only have one relative example which is 2Bromo-LSD which is not a hallucinogen but shows promise for Cluster Headache Treatment. http://en.wikipedia.org/wiki/2-Bromo-LSD Well, Bromo-DragonFLY and 2C-B are obviously both active, so a bromine atom in a compounds chemical makeup is not enough to render a compound inactive. But I'm also no chemist, so I don't know how the position of the bromine atom(s) might alter a compound's potential for activity. depends on the bulkiness of the overall molecule. halides are quite bulky themselves "Nothing is true, everything is permitted." ~ hassan i sabbah "Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
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DMT-Nexus member
Posts: 2151 Joined: 23-Nov-2012 Last visit: 07-Mar-2017
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benzyme wrote:Entheogenerator wrote:Muskogee Herbman wrote:I'm no chemist, but I woner if the Bromo makes the hallucinogen inactive, I only have one relative example which is 2Bromo-LSD which is not a hallucinogen but shows promise for Cluster Headache Treatment. http://en.wikipedia.org/wiki/2-Bromo-LSD Well, Bromo-DragonFLY and 2C-B are obviously both active, so a bromine atom in a compounds chemical makeup is not enough to render a compound inactive. But I'm also no chemist, so I don't know how the position of the bromine atom(s) might alter a compound's potential for activity. depends on the bulkiness of the overall molecule. halides are quite bulky themselves How do you tell from sight what kinds of molecules will have activity at certain receptors? Do you know that shape of the active site of the 5-HT2A? I also see people do this with opioid drugs, saying "XYZ will obviously be more potent because the ABC in the 123 position." "There are many paths up the same mountain."
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analytical chemist
Posts: 7463 Joined: 21-May-2008 Last visit: 03-Mar-2024 Location: the lab
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that's precisely how it's done, using visualization programs like Pymol, Sybyl, and Discovery Studio. Of course, the molecule has to fit in the binding pocket of the active site. Inhibitors typically bind allosteric sites. it's not always cut-and-dry by looking at what position a functional group is, if a compound will be active or not, especially when stereochemistry is involved. "Nothing is true, everything is permitted." ~ hassan i sabbah "Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
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DMT-Nexus member
Posts: 2151 Joined: 23-Nov-2012 Last visit: 07-Mar-2017
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benzyme wrote:that's precisely how it's done, using visualization programs like Pymol, Sybyl, and Discovery Studio. Of course, the molecule has to fit in the binding pocket of the active site. Inhibitors typically bind allosteric sites.
it's not always cut-and-dry by looking at what position a functional group is, if a compound will be active or not, especially when stereochemistry is involved. Do you mind if I keep asking you questions? I'm trying to study molecular neuroscience at school, but these questions about psychopharmacology are a little beyond the professors I'm currently talking to. What causes some molecules with similar binding profiles to have different effects? DMT and 5-MeO-DMT are both 5-HT2AR agonists, but produce subjectively dissimilar effects. I know things like the rate at which a molecule crosses the BBB can effect things like come-up intensity, but variations in how visual a drug is (like N,N vs. 5-MeO) seem like they would be caused by something else. I also know there are 5-HT2AR agonists that don't have psychedelic effects. Is it possible that different molecules change protein conformation in different ways, causing different downstream effects? "There are many paths up the same mountain."
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analytical chemist
Posts: 7463 Joined: 21-May-2008 Last visit: 03-Mar-2024 Location: the lab
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yes. some may act allosterically as partial antagonists on receptors. this is common with structurally complex molecules, like ibogaine and LSD, which display stereochemistry. this may account for the various somatic effects experienced, and why higher doses inhibit some effects, and enhance others. one of the central tenets in biochemistry is that structure determines function; and while this is largely used to describe macromolecules (proteins), this also applies to ligands (small molecules). "Nothing is true, everything is permitted." ~ hassan i sabbah "Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
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member for the trees
Posts: 4003 Joined: 28-Jun-2011 Last visit: 27-May-2024
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^..what benzyme says,
and also the compounds to do not merely act on the 5HT2 receptors (which themselves have a number a sub-types eliciting different CNS and physiologic functions)..they act on other receptors as well..e.g. DMT and NMT are also TAAR1 agonists, amongst other things..
(ps. Km values of 5-Br-DMT i do not know of)
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