A few buddies of mine tried taking DMT on the come down of a mushroom trip and again six hours afterward and experienced very mild effects (mostly just an incredible buzz with extremely mild visuals) on a breakthrough dose. They tried this again a few weeks later after taking mushrooms (this time waiting 40 hours) and had the same outcome. Has anyone experienced this? Research claims that their shouldn't be a cross tolerance, but how could this be? In the name of science they tried it once more and still only experienced very mild effects. Any thoughts?
Thanks.

maybe it was just one of those wierd DMT things, i ate some libs at the weekend and my magic worked just fine.

Cant say ive heard of this predicament before and its strange that it persisted on 2 different sessions. Was the batch of magic tried before hand?

Yes, the magic has been used a couple dozen times before and between the mushroom trips and works perfectly. However, i'm very curious about the possibility of cross tolerance because if you look at the molecular structure between psilocybin and dmt the only difference is that psilocybin has a dihydrogen phosphate group attached to it. The two are very similar and even during trips you can see the similarities present in the visuals at hand.

Anecdotal, but I noticed what must have been some cross tolerance combining lucy and DMT.

Essentially, no trip recent enough beforehand for either me or my bud to impact it. We both did a small dose of DMT on the Friday, then 200ug each at 12 PM Saturday, plus another 100ug each around 3 PM. While coming up, I did .03 DMT, my friend didn't. I also did a further .03 later one after the peak. I finished the trip entirely at 12 AM Sunday morning, but my friend went for another 5-6 hours.

This has happened to me before. I ate an eighth of cube sis and the next day I couldn't get anything more than threshold effects from the spice

I've been wondering for awhile if there is a kind of rebound production of monoamine oxidase to account for the psilocybe flooding our brains, as mao is essential to protecting the brain from high levels of monoamines, and can't differentiate between one or the other. Since mushroom tolerance lasts a half a week or so it stands to reason that other monoamines would also be oxidized quickly during that time. Our brains learn that there's a surplus of something that could potentially be a threat to survival and attempt to correct it until there isn't a threat anymore.

In trying to theoretically link that to the "afterglow" effect of mushrooms, the increase in mao temporarily may also clear more than average amounts of feel-good brain chemicals, signalling an increase in production, as serotonin, dopamine, endorphins and whatever are also oxidized more rapidly perhaps our bodies compensate by making more.

That might also explain how taking an maoi can lead to antidepressant effects as your brain might jack up mao production afterward, clear happy chemicals more rapidly and lead to your body making more for those 3-4 days.

Speculating on the difference between DMT and Psilocybe and why one might affect this process longer than the other, makes me think its associated with their half-lives in the brain. We all know how long a DMT trip last when compared to a mushroom trip. Psilocybe effects diminish in like 6-8 hours and DMT in like 20 minutes. You can take another DMT hit before long but if it was a direct correlation then you couldn't take a solid DMT hit after mushrooms for quite some time.

The theory also would account for large doses- taking multiple psychedelics while coming up or just large doses of say mushrooms could compromise this more quickly and actually create shorter trips. Your brain doesn't care about whether or not you trip, its function is basically to allow you to live.

THe part that is confounding is why if DMT is metabolized to psilocin that there should be much difference- keeping in mind that one can withstand gut metabolism (coincidentally about a 9 hour process) so regardless, psilocybin is going to metabolize out of the body for awhile when compared to DMT.. idk.

Idk if that makes real sense. I know it all sounds loose and slapped together. I plan to ncbi the ideas later and perhaps support these ideas. I'm not a doctor but if I was junk like this woulda been my thesis.