Had eaten some leaves of freshly harvested Nicotiana Glauca yesterday and felt actually quite noticeable effects. Felt more blurry and subtly intoxicated than with peganum harmala.
Felt a little similar to peganum but i would like to know if this plant has any history in divination practices or if it could potentially be the MAO-Inhibitor in an Aya-type brew with some phalaris stenoptera or a good Acacia.
Might conduct some trial tests since the activity of whatever alkaloids are in N. Glauca surprised me with its seemingly potent constituents but were not nauseating, just had "drunk eyes" but body felt calm and almost similar the body feeling of peganum harmala.

PLEASE BE CAREFUL!

Nicotine poisoning can be lethal.


http://www.cdc.gov/Niosh/idlh/54115.html


Also, here's an article from the Journal of Toxicology, "Acute Poisoning from the Ingestion of Nicotiana glauca" that details a case study of the plant you mentioned. Unfortunately I do not have access to the full text.

~wap~

Everything wap said.

Acute respiratory failure due to Nicotiana glauca ingestion

Thanks for looking out. Found this as well.: http://www.shaman-austra...ndex.php?showtopic=19917

The effects felt like it would be a good addition to aya brews.
Am still leery on the apparent toxicity of many plants especially phalaris.

Will play it safe for sure.

As with all poisons/drugs the dosage is key. Anabasine is less toxic thn nicotine IIRC.The respiratory failure case study doesn't state the amount of leaf that the woman ate which would have been a very interesting and useful piece of infomation. I have smoked N. glauca in the past and enjoyed it. I also smoked cigarettes for 24 years. Never ate either one though.

Tangentially related tidbit: When I was in Ecuador the Quichua shamans required everyone in our group to smoke cigarettes throughout our ayahuasca ceremonies. I don't recall if they ever explained why they did it that way, but it was evidently part of their normal practice. Nicotine does have some MAOI activity if I'm not mistaken, don't know about anabasine.

I don't think nicotine has maoi effect. Smoking tobaco has this effect and it comes from others molecules (natural or additives).
And the mix nicotine/maoi provokes addiction

Actually, I think nicotine acts as an MAO-B inhibitor. Can anyone else chime in here? Also, I don't know about the alkaloid profile for Nicotiana gluaca, but N. rustica contains heaps of nicotine, along with harmala alkaloids like harman and norharman. Tobacco has been used in ceremony with ayahuasca for many hundreds if not thousands of years so I don't quite buy the addiction idea. Definitely important to proceed with extreme caution though when dealing with such toxic plants.

You could be right Bancopuma when you say "nicotine acts as an MAO-B inhibitor" but i didn't find any information about that. On the contrary.

And about the potential dependence of the mixture nicotine / MAOI : this.

I agree with you "Can anyone else chime in here ?"

Pleasant smoke and felt calming. Threw in some flowers as well.

Ah good find. And it does seem like the other compounds underplayed in tobacco with regard pharmacological effect, at least on MAOI enzymes. But study wise, what behaviourally applies to caged rats may not necessarily apply to human beings. Interesting both ayahuasca (very rich MOAI source obviously) and tobacco are considered some of the most highly revered medicinal plants in the Amazon and have been so for a very long time, and are often used in healing ceremonies together...I'm not sure a strong case for addiction can be made in this context, although I'm sure it does occur (particularly given the large doses of both MAOI beta-carbolines and nicotine ingested). If addiction was such a risk factor of such a combination I doubt these plants would hold the degree of reverence they do among the healers that use them.

From: http://vinifornasier.blo...itualistico-do-rape.html



Translated into English by ERIN:

I'm sure a drug used traditionaly and culturaly doesn't have the same addictive potential when it is used outside the cultural framework.

Who told you i'm not a rat ?

Any nexians have experience with this certain strain of tobacco. Have found multiple sites suggesting its traditional use in oral and smoked preparations. Supposedly one site mentions 5 fresh leaves are psychoactive.

Intrigued by the looming question of what exactly is contained within Nicotiana Glauca, I did some digging and found some viable data.

Initially I entered communication with this plant under the false pretense that Anabasine was the sole constituent. Safety first friends. Always take the time to research what you are ingesting, even if you think you know it won't harm you.
I have had good experience with this plant either way via multiple forms of administration. Though not an extensive relationship, I would advise anyone who lives around this plant to learn other species of Nicotiana before inviting this valuable medicine into your body. Smoke is used as a cure to nicotine addiction in some countries, basically why I assumed there to be no nicotine or its derivatives contained within N. Glauca. There are bits and pieces on references to Tree Tobacco's ethnobotanical history though I would recommend conducting a search for yourself if at all interested in the subject of this plant. Misinformation on the part of internet forums and ethnobotanical suppliers can lead to some unexpected or inevitable consequences.

For example:
https://www.erowid.org/e...riences/exp.php?ID=38989
Nicotiana Glauca DOES have the potential to synthesize Nicotine
Here's further readings...

Pregnant Cows Feeding on Nicotiana Glauca
https://www.researchgate...teratogen_in_plant_parts


Alkaloid Composition of Nicotiana species(good references)
https://www.degruyter.co...-0610/cttr-2013-0610.xml

An Experimental Analysis of Alkaloid Production in Nicotiana: The Origin of Nornicotine

http://www.jstor.org/dis...4&sid=21106861335513

Nicotiana Tabacum and N. Glauca hybrids inheriting alkaloids

http://www.cabdirect.org...C4022B350CBD0352C27CDA3E

Prickly Pear and Tree Tobacco for Ethanol Production in Semi Arid Regions
http://www.greencarcongr...11/almeria-20091112.html

The aberrant formation of (−)-N-methylanabasine from N-methyl-Δ1-piperideinium chloride in Nicotiana tabacum and N. Glauca
http://www.sciencedirect...le/pii/S0031942200865085

Metabolism of Nicotine in Nicotiana Glauca
http://www.sciencedirect...cle/pii/0031942274851010

i've read harmala/harmalol are main MAOI's in tobacco.

from the harmaline wiki and harmala wiki;
"The harmine-containing plants listed include tobacco, Peganum harmala, two species of passion flower/passion fruit, and numerous others. Lemon balm (Melissa officinalis) contains harmine.[18]

Harmala alkaloids are also found in many other plants, such as tobacco and passion flower."

Anyone who has smoked tobacco during a trip should know it takes the trip to another level.