Next draft up;
NN-Dimethyltryptamine or DMT for short, is a chemical substance with a number of psychoactive effects. DMT intrigues many minds anthropologically speaking, because of it's use in an entheogenic context. We see it in religious, shamanic and spiritual practices all around the world. It's part of the tryptamine family of monoamine alkaloids and It's one of the most powerful yet mysterious psychedelics in existence.
Some would say to classify DMT as just a drug would be doing it a great injustice, as DMT seems to invoke a boundary dissolving experience so profound that it raises many questions regarding the nature of reality and our place within it.
It is important to realize at this point, that the experiences one has on DMT may be very difficult for some to integrate. It's very common practice, that persons seeking a DMT experience, will spend a year or more doing research in preparation before even coming into contact with the physical substance.
Changes in dose and method of administration can drastically affect DMT's subjective effects and these can range from short-lived, milder psychedelic states, to powerful immersive experiences. It's because of the intensity of these experiences that an element of danger is starkly present for the inexperienced user. If you find yourself in a state where you can no-longer perceive your body, how do you make sure your body remains safe? This is the first step of many that must be taken to assure the safe use of any psychedelic compound.
The pharmacology of DMT is similar to that of other well-known psychedelics. It affects the receptor sites for serotonin (5-hydroxytryptamine) in much the same way that LSD, psilocybin, and mescaline do. Serotonin receptors are widespread throughout the body and can be found in blood vessels, muscle, glands, skin and the brain. As DMT resembles the basic structure of neurotransmitters, when ingested it's capable crossing the human blood-brain-barrier, allowing it to dramatically affect human consciousness.
From 1955 DMT has been found to occur naturally in at least fifty plant species belonging to ten
different families, and in at least four animal species, including one gorgonian (Gorgonians are closely related to coral) and three mammalian species (Humans included).
In 1931 Canadian chemist Richard Helmuth Fredrick Manske (1901โ1977) was first to synthesize DMT and
its discovery as a natural product is generally credited to Brazilian chemist and microbiologist Oswaldo Gonçalves de Lima (1908โ1989)
In 1946, Gonçalves de Lima isolated an alkaloid he named nigerine from the root bark of Mimosa hostilis.
However it was later shown in a case review by Jonathan Ott that formula for nigerine as determined by Gonçalves de Lima could only match a partial or impure form of DMT.
It wasn't untill 1959, when Gonçalves de Lima provided American chemists a sample of Mimosa hostilis roots, that DMT was unequivocally identified in this plant material.
At this point its a nice chance to debunk the claim that endogenous human DMT is produced by pineal gland. I'm afraid presently (when this video was published) there is no evidence to support the claim that DMT is produced in the pineal or the brain for that matter. This is just speculation by Dr Rick Strassman (of spirit molecule fame) due to his own interests in the pineal gland. So far in humans, the key enzymes necessary for DMT synthesis have not been found in the brain, so it seems more likely that it's produced elsewhere in the body. Some recent research has shown that these enzymes
are present in the pineal gland of primates, although nothing has really been proven yet, so we must avoid stating speculation as fact before the data comes in.
The equally as unfounded is the connection of DMT to dreams, and the idea that DMT is released when we die, both are also speculation with no real evidence to back them up. One thing we do know is true, is that DMT is produced in the human body, we're just not sure where. It's present at all times but only in trace amounts and the reason for this is still unknown.
A very interesting Preliminary Observational Study in Canada (Published June 2013 in Current Drug Abuse Reviews) has shown DMT may show promise in psycho-therapy with sufferers of addiction and stress disorders.
The study combined four days of group counseling with two expert-led ayahuasca ceremonies. Ayahuasca also commonly called yagé, is a psychedelic brew made from DMT containing shrubs. It's commonly used by a number of shamanic cultures throughout Northern South America and Brazil.
In the study data was collected on from 12 participants on several psychological and behavioral factors related to problematic substance use. Pre-treatment and and qualitative data assessing the personal
experiences of the participants six months after the treatment are all included in the research.
(Link in the description;
http://www.maps.org/ayah...ca/Thomas_et_al_CDAR.pdf)
The study showed; "mindfulness, empowerment, hopefulness, quality of life-meaning, and quality of life-outlook showed statistically significant improvements over time.". One of the female subjects (age 41) said of her experiance;
โBefore the ceremony I was
struggling with my addiction, crack cocaine, for many years.
And when I went to this retreat, it more or less helped me
release the hurt and pain that I was carrying around and
trying to bury that hurt and pain with drugs and alcohol. Ever
since this retreat Iโve been clean and sober.โ
A male subject (age 30) provided this insight:
โWith my last experience with the
ayahuasca, I really faced myself. Like, my fear, my anger.
Which really, I think is a big part of my addictions. Like,
running away from myself pretty much. And I think I
overcame that in the ceremonies. That was a pretty big deal
for me . . .โ
It must be underlined that this research is no reason for anyone to jump on a plain, seeking out a shaman to quick fix to their addictions. There have been instances of death caused by mock shamans profiteering from the resurgence of interest in ayahuasca and instances individuals mistakenly taking Brugmansia.
(links in the description;
http://motherboard.vice....oiling-ayahuasca-tourism)
All this should underline the need for more real scientific research into DMT and a need to open up some real discussion in public forums to challenge our present attitudes to not just DMT but all psychedelics.
~"We've been stuck searching for what we already own"~
~"I AM"~