Perhaps you are already familiar with this:
DMT is very soluble in xylene, toluene, acetone, IPA, methanol, ethanol, DCM, chloroform, ether, MEK, limonene, butanol and isomers to name a few.
DMT is soluble in naphtha, hexane, heptane but almost insoluble in these solvents at freezing temperatures
DMT is almost insoluble in water.

... and this https://wiki.dmt-nexus.me/XlogP


I know a fellow who was thinking about using a mixture of aliphatic hydrocarbons (distilled hexanes and heptanes, BP:90-110C) for Acacia defatting and re-crystallization. The freebase alkaloids would have been separated with chloroform/TCM. It would have been distilled off and changed to much more DMT-selective heptane and the pulls would have been done from this. The heptane-insoluble part of alkaloid-containing solution would have been used as is or mixed in a suitable ratio with the crystals.

However, TCM may not be such a good idea. Here's one point which hasn't gotten any attention here: while chloroform/TCM is a good solvent for freebase DMT, it would be used at a pH near 13. This may be a problem since TCM breaks down when in contact with NaOH solutions: http://en.wikipedia.org/wiki/Dichlorocarbene
Because of this this fellow is now considering other options.

If one would want to have DMT crystals and the other alkaloids separately in the end, what would be the best way to achieve it with Acacia?

Could TCM be used for defatting of the acidic solution without pulling any DMT-salt with it?
TCM would be very nice for defatting since its density is higher than water and would sink below the (hopefully still) alkaloid-containing water phase along with unwanted heavy particles and fat. Traces of TCM would also boil away when the water phase would be heated up.
If one would then want to draw as much freebase alkaloids in to the non-polar solvent, what would be the best choice? How would you then separate the DMT from the rest? I'm sure most of you would recommend naphtha or D-limonene, but I don't know what the first one really is (what is the composition, is there another name for it outside US, and why it would be more non-selective for alkaloids than the hexane/heptane mix?) and the second option would preclude freeze pecipitation.
Is there any way to stop TCM from reacting with stuff at high pH?

Why not use limonene and fumaric acid? Then you could freebase the fumarates and paste and pull with heptane and pull the remaining alkaloids with anhydrous IPA, evaporate and mix with the crystals.
You could of course just paste and pull with IPA in the first place to yeild full spec wax/goo.
Naptha is lighter fluid, liquid hydrocarbons , like the seas of Titan
There really isnt a need to use such a toxic solvent such as chloroform.

Thank you for your reply!

I too have understood that naphtha would be the same as e.g. Zippo lighter fluid. But this wouldn't explain why it would be a broad spectrum solvent for alkaloids whereas aliphatic hydrocarbons such as hexane/heptane would be extremely selective for just DMT. Does naphtha contain some oxidized hydrocarbons or something that would make it a bit more non-polar?

D-limo/fumarate wouldn't be an option since my fellow thinks it's too troublesome.

What does "paste" mean?
I guess IPA means isopropanol/2-propanol? If one uses it to separate all the alkaloids from the defatted pH 13 solution, how much (ml/g of Acacia powder) is needed?

Could one just mix IPA and heptane and then distillate the IPA off after the extraction to yield heptane solution with mostly DMT in it, or would it be contaminated with something undesirable? Could one just start pulling from this solution after the IPA is boiled off and all the non-soluble stuff removed before freeze precipitation?

I think TCM would still be excellent for the defatting if one just can be sure that none of the alkaloids will be in it at pH 3. Since this is uncertain, my fellow was also thinking about degreasing with hexane/heptane. Sure TCM is toxic and harmful to the environment but if one uses a distillation system, the only time when ventilation is needed is when the liquids are being poured from one container to another.