"CYP3A4 is also inhibited by Grape juice and causes dangerous interaction with common antipsychotics"
If it's main effect comes from this Enzyme then Grapejuice is a more effective inhibitor for this Enzyme and this can easily be tested. Anyone have some experience with Grapejuice here?

That it has MAO-inhibiting properties and MDMA-enhancing ones at that are interesting. But my knowledge does not go far into the biological territory. I still wonder what the mechanism is how any substance can excert MAO-B inhibitory effects in the first place.

Err. Yah. Darn english names. Turmeric; Gember family. Not Ginseng. I was confused. But still very interesting.

I don't feel as this is a hijack, but an extension of the topic: Any points of view about nutmeg/myristicin??

Nutmeg Effects - wikipedia:

In its freshly ground form (from whole nutmegs), nutmeg contains myristicin, a monoamine oxidase inhibitor and psychoactive substance. Myristicin poisoning can induce convulsions, palpitations, nausea, eventual dehydration, and generalized body pain.[15] It is also reputed to be a strong deliriant.

"Is it your understanding that Bioperine/Piperine would potentiate Ayahuasca and/or Iboga?"

yes the procedure is different though (and it is more safe) DO ME A FAVOR AND DO NOT TRY THIS UNTIL TOMORROW WHEN I FULLY EXPLAIN HOW TO INDUCE MAO A AND OR B

what your looking for is piperidine made from putting black pepper into a coffee filter and sealing it with a twist tie and pouring boiling water into a cup with this teabag and i would imagine within 15 minutes it should contain a fair amount of piperidine this is different from the compounds you refer to "Bioperine/Piperine", i think piperidine may also be made from taking the same kind of coffee filter tea bag and putting it in 99% IPA rubbing alcohol (with ZERO denaturalants) and shaking daily for 1-2 weeks then evaporating the IPA (i think in the fridge is best) and this should yield piperidine crystals (i could be wrong this could be the method of producing the compounds you are referring to).

from what i recall:
piperidine = NOT the solids
piperine = YES the solids

piperidine is the one you want for cycling.

now. KP because you are a mighty warrior i have no fear helping you pry your left hand off the lid of the box (:

i cannot speak of iboga (i will research the chemical structure of it and its metabolites tomorrow possibly and get back to you)

but yes if you take pepper tea filtered of solids 1 hour and again 5 minutes before ayahuasca you can produce a WEEK OR MORE long ayahuasca journey this WILL NOT be with the gentle carrying over into the next couple days, this will be terrifying and HORRORS THAT CANNOT BE THOUGHT UP. it takes more than black pepper tea filtered of solids, it is very late at night i promise to finish filling this in first thing tomorrow, you could use the method i posted:

"
timing goes like this:
hh:mm
00:00 L-lysine 1-2 gram with cup water (or wait till 00:15 and use pepper tea without solids instead of L-lysine)
00:45 20 drops each star anise extract and almond extract (both non artificial) and a 100mg caffeine tablet with tiny sip water
01:00 ingest desired compound
01:15 be ready, this is not for the beginners, regardless of compound used

if you want a shorter experience that is more visual and less potent use lecithin in place of L-lysine or pepper tea this is a very good idea for beginners in this type of experience, it lasts dramatically shorter and is much easier to get used to before jumping into a multi day experience."

also if your using aya you can take the caffeine tablet and crack into into 1/4th and only take a quarter of it, or remove it altogether and use an extra 10-20 drops of the 2 extracts each. i am not entirely certain of how strongly you may feel stimulated combining caffeine with aya even if beforehand. it may be dangerous is why i suggest against. i have many MAOI but not actual aya vine to test the safety personally, i think somebody at herbsmax may have tested it beforehand and got extreme blood pressure.

please try this part in bold before you use try it with pepper tea or L-lysine PLEASE



now it is possible to use this method to do a smaller dose and have it last for very long with a much smaller potency, and when you get comfortable with small potency long lasting versions, then i would advise you very gently bump the dose ever so slightly.

... We don't want anyone dying of electrolyte loss or even worse, some other unintended consequence of pepper poisoning (piperidine poisoning). Remember, Ayahuasca is under very strict scrutiny these days. If someone gets hurt or dies in such experimentation and it is tied to Ayahuasca in any way, this endangers the whole community.

Consider the danger of piperidine poisoning: people need to be made aware that piperidine is closely related to the toxic principal in hemlock, so people would need to be quite well versed so as not to make a fatal mistake in confusing piperidine with piperine. Piperine is the safe alkaloid; piperidine is a toxin related to coniine in hemlock, the tea of which was used to put Socrates to death:
Reference: http://en.wikipedia.org/wiki/Piperidine

Furthermore, who can predict the consequences of a toxin such as piperidine interacting with harmine? Recall how toxic nicotine is to the body, and with harmine, even more so, especially when added to a brew.

This just doesn't sound advisable. It just doesn't sound safe to be playing with hemlock-like toxins.

For those science fans, it might be of interest to you to know that piperidine functions in much the same way as the famous Amazonian curare used in poison darts. Both poisons (curare and piperidine) block respiration by paralyzing the lungs, but what is fascinating is that the paralysis is only temporary. This means that if an affected person is kept breathing through artificial respiration until the pulmonary paralysis wears off, they can recover completely!