Couldn't find much discussion on whether or not the dosages of RIMAs that would be ingested from smoking changa composed of just dmt and caapi leaves would pose any concern, so I was just wondering if any has had any experience with respect to that. Seems like they would be too minute to be of much concern. I have a friend that I think may benefit from DMT and the changa mix I currently have seems especially rewarding.

The amount of Harmalas that are in Caapi leaf or even Passion Flower leaf, when smoked, will not negatively interact with SSRI's. My brother is on Zoloft, and the only interaction i can tell thus far is he needs higher doses of DMT to feel much of anything.

The problem is that regardless of whether you're taking in RIMAs or not, the SSRI itself will make smoking DMT largely a pointless endevor, unless you feel like radically upping your dosage.

SSRIs increase the amount of free 5-HT floating around the brain, which means that a greater percentage of the 5-HT2A receptors (which are the receptors that DMT and other psychedelics act on) are likely to be already bonded to a 5-HT molecule, so fewer DMT molecules can exert an effect. Consequently, it takes much higher doses for any psychedelic to be active if you're on an SSRI.

I had a friend on Luvox who wanted to trip with me. I ate 2g of P. Cubensis and had a vivid, visionary experience. He felt absolutely nothing, even after five or six really heavy bong rips (which really bring out mushrooms).

That said, SSRIs and RIMAs probably shouldn't be mixed, esp. since you already need a way higher dose of changa than your ordinarily would.

Blessings
~ND

PS: if I got the pharmacology of SSRIs and psychedelics wrong, anyone can feel free to correct me.

My ex was on SSRIs, can't remember which one, but it had no effect on the potency of mushrooms or dmt whatsoever. 2g of mushrooms had the same effect on her as it did me. Same with dmt dose sizes.

I'm no doctor but I assume it would just not be a good idea to intake any amount of harmala with SSRIs. Even though there are RIMAs in cigarettes, although I do not know in what amounts.

Mixing ssri's with dmt or mushrooms is NOT THE SAME AS MIXING SSRI''S WITH CHANGA!!!
Changa contains MAOI's. That's the danger, not the dmt.

I would never mix RIMA's or MAOI's with SSRI's. You're playing with fire. No matter how little.

Why take the risk?
Theres a very real possibility of a harmful effect. There may not be that much in the changa but it will be a concentrated amount entering the brain.
Noone on here can give medical advice or predict the outcome its simply a well known fact that MAOI and SSRI do not mix well. Again, why take the risk?