DMT-Nexus member
Posts: 29 Joined: 03-Jan-2014 Last visit: 01-Apr-2014 Location: God's Subconscious
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Okay this is a cactus thread. A little out of place in this community, but I want to know about dosing with San Pedro, or even peyote or other mescacti. My main question is, if I were to get a few St. Pete cuttings, and I prepare all of them at once, and separate the sludge into say thirds for three cuttings (yes, I actually have a plan here) if I find that after an hour or two, I don't really feel it (and I've learned to wait patiently for the teacher to come to me; I'm on the plant's time, not my own), can I drink another measure of the sludge (woe unto my stomach) to boost it? At that point I'd probably overshoot my goal and end up with more mescaline in my system than needed, but St. Pete is a tricky cactus as it is. In my small experience, too much mescaline is never enough when it's all over. I really kind of want to be laid out and humbled by this wonderful plant teacher, as is generally my goal when tripping in general; I'm not there to enjoy the ride so much as learn a lesson. DMT is another story. I usually just like to wander aimlessly in hyperspace. It's way too short lived to really take anything away from it, without MAOI. Another story for another thread. Or is it? Would harmalines be a good or bad idea with mesc? I feel like with the nature and length of the experience, MAOI would probably be a good thing, like for psilohuasca, but one can never be too careful when mixing things with MAOIs. You have been put to no test but such as is common to man: and the Spice is true, who will not let any test come on you which you are not able to undergo; but he will make with the test a way out of it, so that you may be able to go through it.
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Posts: 6739 Joined: 13-Apr-2009 Last visit: 10-Apr-2022
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Hey there! You are on the right track.
Brew 3 ft. and start with 1 or 2. You can even do 3 if you want.
Instead of waiting 1 hour wait 3. Sometimes Pedro has taken that long to hit me.
You can drink it all at once or a cup every hour or whatever feels right to you. It lasts a long time!
And youre right it is hard to get too much. Its one of those "the more the merrier" type medicnes if you ask me.
Harmalas can be used with Pedro. Check the wiki for our substance interaction page theres some info on there. Also threads entitled San Paapi for pedro and caapi mixed. The harmalas kill the stimulation and make it kind of dreamier. Definitely worth experimenting but some dont seem to like it for that reason.
Have fun be safe and love the mesc!
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dysfunctional word machine
Posts: 1831 Joined: 15-Mar-2014 Last visit: 26-Mar-2025 Location: at the center of my universe
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NONONONO don't use harmala with cactus! Cactus contains significant levels of tyramine AFAIK. Bad interactions!
Even extracted and purified mescaline with harmalas is listed as dangerous. You should really investigate this combination thoroughly before actually ingesting anything.
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Posts: 6739 Joined: 13-Apr-2009 Last visit: 10-Apr-2022
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Source for tyramine levels in cacti sp? Never had an interaction and have done this synergy multiple times. San pedro and Peruvian torch have been confirmed to be ok with harmalas. Mescaline is fine. There's no amphetamine group on the molecule. There are also reports of achuma and caapi. I remember Ekoostik drank 3 ft. of t. Bridgessi with a solid caapi dose and was great. I cant find the thread but I believe it was 100g caapi. Doesn't seem too risky if you ask me. Check the substance interaction page in the wiki  and see the San Paapi threads. Leave myths in the past.
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dysfunctional word machine
Posts: 1831 Joined: 15-Mar-2014 Last visit: 26-Mar-2025 Location: at the center of my universe
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۩ wrote:Source for tyramine levels in cacti sp? https://en.wikipedia.org...opsis_pachanoi#Alkaloidshttp://azarius.net/auction/44/auction_1243947339/https://mycotopia.net/topic/70852-san-pedro-maoi/۩ wrote:
Never had an interaction and have done this synergy multiple times.
San pedro and Peruvian torch have been confirmed to be ok with harmalas.
I honestly feel that would be good news, not having to ingest all those slime cucumbers for a decent effect. It would be great to have better and broader confirmation of your experimental data. Still the reports of tyramine content are abundant and I felt and still feel it is better to err on the safe side. I have had some harrowing interactions with MAOIs and some particular foodstuffs that caught me by surprise, so I've become a bit more cautious in that respect. I will never eat falafel balls again an hour before pharmahuasca.. ۩ wrote:
Mescaline is fine. There's no amphetamine group on the molecule.
I never wrote that, or at least I deleted it before posting. But mescaline still is a phenethylamine and pretty close to a catecholamine. ۩ wrote:
Leave myths in the past.
So glad you're not Terrence McKenna 
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DMT-Nexus member
Posts: 635 Joined: 20-Sep-2013 Last visit: 28-Dec-2020
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Id like to chime in here wit a dosage question myself if I may. I know theres so much variability in dosage and potency of SP cacti. If one has a 12in cutting and wanted to blend it up and brew tea of it, would it be safe to assume that 1 cutting would be one dose? "A troop of elves smashes down your front door and rotates and balances the wheels on the after death vehicle, present you with the bill and then depart. And it's completely paradigm shattering. I mean, ya know, union with the white light you could handle. An invasion of your apartment by jeweled self dribbling basketballs from hyperspace that are speaking in demonic Greek is NOT something that you anticipated and could handle!' -T.M.
The posts and stories by this member are simply for fictional entertainment purposes only and do not reflect any 'real life' occurrences.
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Posts: 6739 Joined: 13-Apr-2009 Last visit: 10-Apr-2022
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Depends. Try 1 ft. Then go for there. Its a good place to start.
Also dont blend it. Its extremely hard to filter and makes it even more disgusting. Chunks are perfect.
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DMT-Nexus member
Posts: 12340 Joined: 12-Nov-2008 Last visit: 02-Apr-2023 Location: pacific
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pitubo wrote:NONONONO don't use harmala with cactus! Cactus contains significant levels of tyramine AFAIK. Bad interactions!
Even extracted and purified mescaline with harmalas is listed as dangerous. You should really investigate this combination thoroughly before actually ingesting anything. There is no evidence for harmine/harmaline and tyramine interactions. I eat tyramine all the time with ayahuasca. I often come down and eat aged raw cheese and drink fermented teas. Long live the unwoke.
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dysfunctional word machine
Posts: 1831 Joined: 15-Mar-2014 Last visit: 26-Mar-2025 Location: at the center of my universe
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jamie wrote:
There is no evidence for harmine/harmaline and tyramine interactions. I eat tyramine all the time with ayahuasca. I often come down and eat aged raw cheese and drink fermented teas.
http://www.ncbi.nlm.nih.gov/pubmed/3839173 I did not actually read the full article, but the abstract states harmaline "shifted the dose-response curves for tyramine and serotonin" at least in lab rats. When I first began taking pharmahuasca, I was apprehensive about MAOI interactions, fearing I would have to forego coffee for at least a day. Soon I found out I could drink a whole can of coffee before pharma. I would eat sourdough bread with cheese for lunch and do pharma in the afternoon. No problem. Then one time I did actually fast properly before pharma and what a difference did it make! No body load of any kind, just "visions". I found out just how much coffee causes restlessness, the sourdough bread and cheese caused the colics and belly spasms and other physical discomfort. A handful of licorice candy caused feverish reactions. I gained some respect for the practice of the dieta and I discovered that fasting does pay off. Lately I suffered a lapse of attentiveness and ate "just a few" falafel balls before doing pharma. The effects frightened me as I spent several hours dealing with what felt as a severe poisoning. I suspect that "lupine alkaloids" from chick peas (these things have many names, not all listed in the MAOI warnings) contributed to the symptoms. So in my experience, usually there is no big problem with food interactions. But sometimes there is and it can turn out pretty bad and make your situation feel way out of control. Better be safe than sorry. You also write about eating tyramine-rich foodstuffs after ayahuasca. What is your experience when eating such before (or during) ayahuasca? I think there is possibly a difference there, as foods taken when harmaline is out of your system will not interact, while foods still in the digestive system will interact when harmaline is ingested on top.
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DMT-Nexus member
Posts: 1892 Joined: 05-Oct-2010 Last visit: 02-Oct-2024
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pitubo wrote:Even extracted and purified mescaline with harmalas is listed as dangerous. You should really investigate this combination thoroughly before actually ingesting anything. Listed by whom? The closest to a clear answer I have got on that from this forum is that (the poster was later corrected) 'mescaline releases serotonin'. Which it doesn't. Countless people have taken cacti resins, teas and pure mescaline with harmalas with no negative effects. Not that this justifies doing it, but coupled with the lack of a solid reason to avoid it, is there really an issue? None of these links give any quantitative evidence. Art Van D'lay wrote:Smoalk. It. And. See.
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Posts: 6739 Joined: 13-Apr-2009 Last visit: 10-Apr-2022
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It harmalas reacted negatively with cacti or mescaline I would be a dead man.
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DMT-Nexus member
Posts: 635 Joined: 20-Sep-2013 Last visit: 28-Dec-2020
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Youre saying just cut it into chunks and brew tea that way as opposed to brewing with blended cacti? "A troop of elves smashes down your front door and rotates and balances the wheels on the after death vehicle, present you with the bill and then depart. And it's completely paradigm shattering. I mean, ya know, union with the white light you could handle. An invasion of your apartment by jeweled self dribbling basketballs from hyperspace that are speaking in demonic Greek is NOT something that you anticipated and could handle!' -T.M.
The posts and stories by this member are simply for fictional entertainment purposes only and do not reflect any 'real life' occurrences.
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Posts: 6739 Joined: 13-Apr-2009 Last visit: 10-Apr-2022
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dysfunctional word machine
Posts: 1831 Joined: 15-Mar-2014 Last visit: 26-Mar-2025 Location: at the center of my universe
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It is good to hear that people tried the combination of cactus with harmalas with positive result. Not everyone reports positive though: https://www.dmt-nexus.me...&m=215661#post215661Still the information regarding this combination I can find online is scarce and contradictory. The best information that I could find on the combination is in 'Trout's notes on the cactus alkaloids' December 2013 edition pages 118-120. The author warns: "Keeper Trout" wrote:".. it IS noteworthy that when alkaloids do occur in cacti it is very often as phenethylamines. Many of the most commonly reported have far greater pressor effects than does mescaline. This factor also holds true for peyote alkaloids other than mescaline, most of which are far more toxic and some of which show greater pressor effects than mescaline. Further, they would interact with a broader range of receptors, are present far more commonly in physiologically active concentrations than mescaline is and, if using the exact same rationale currently contraindicating mescaline, would pose considerably morerisk if combined with a Monoamine Oxidase inhibitor." In the section on MAOI's, Trout also questions much of the current information regarding harmala, even suggesting that the combination with SSRI's and MDMA with harmala may not be as deadly as it has been stated to be. But then someone also reported this: https://www.dmt-nexus.me...&m=213386#post213386 so not lethal does not imply not harmful. See also here: https://www.dmt-nexus.me...&m=216915#post216915Maybe my initial reaction was a bit of a knee-jerk, but after having been bitten myself by awkward harmala interactions, I feel it is better to urge others for caution when discussing this combination. Thankfully, there are no reports of death involving harmalas (that I could find). Nevertheless the effects can sometimes be quite overwhelming and scary. We should not underestimate these, and I would like to see more and better information become available. "Keeper Trout" wrote:"While this demonstrates that some people have combined the two successfully with no apparent toxic effects this still is not proof that it is safe. There is presently a small pool of succesful bioassays but it is not large enough to predict adverse reactions. Only once the number gets into the hundreds of thousands of such REPORTED experiences will we be able to get a good overview. Until then, a slow and cautious approach is urged, with all practitioners attempting to share their experiences, good or bad, however they can."
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Posts: 6739 Joined: 13-Apr-2009 Last visit: 10-Apr-2022
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DMT-Nexus member
Posts: 635 Joined: 20-Sep-2013 Last visit: 28-Dec-2020
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Thanks Joe!  "A troop of elves smashes down your front door and rotates and balances the wheels on the after death vehicle, present you with the bill and then depart. And it's completely paradigm shattering. I mean, ya know, union with the white light you could handle. An invasion of your apartment by jeweled self dribbling basketballs from hyperspace that are speaking in demonic Greek is NOT something that you anticipated and could handle!' -T.M.
The posts and stories by this member are simply for fictional entertainment purposes only and do not reflect any 'real life' occurrences.
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DMT-Nexus member
Posts: 833 Joined: 19-Oct-2010 Last visit: 21-Aug-2023 Location: Planet Earth
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That dang Joe Rogan is such a cool guy! Got a cacti tea tek and everything. --------------------------------------------------*Kash's LSA Extraction* * Kash's Mescaline Extraction*------------------------------------------------------ All things I say are complete and utter ramblings of nonsense. Do not consider taking anything iterated from the depths of my subconsciousness rationally and/or seriously.
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DMT-Nexus member
Posts: 329 Joined: 05-Jan-2013 Last visit: 02-Apr-2024 Location: tingüindolandia
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Can anyone aware me on the Joe Rogan joke?
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DMT-Nexus member
Posts: 635 Joined: 20-Sep-2013 Last visit: 28-Dec-2020
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House ۩ and a few others successfully convinced most of the forum he was Joe Rogan on April Fools day lol, those who were aware that it was April Fools Day (myself and a few others I believe) tried saying it was April Fools Day, the phrase was forum coded to change to something else, I believe it was Advertise Now! day. It was a good laugh. "A troop of elves smashes down your front door and rotates and balances the wheels on the after death vehicle, present you with the bill and then depart. And it's completely paradigm shattering. I mean, ya know, union with the white light you could handle. An invasion of your apartment by jeweled self dribbling basketballs from hyperspace that are speaking in demonic Greek is NOT something that you anticipated and could handle!' -T.M.
The posts and stories by this member are simply for fictional entertainment purposes only and do not reflect any 'real life' occurrences.
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Posts: 6739 Joined: 13-Apr-2009 Last visit: 10-Apr-2022
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https://wiki.dmt-nexus.m...use%27s_Trichocereus_TeaI originally linked you the wrong tek. This one is not listed under the teks for some reason so I forgot about it. My bad!
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