Hello Nexus!

I have been thinking of the theoretical idea to consume a rather large amount of DMT orally without MAOI and get psychological effects. What sort of dosage do you think would be necessary if it's at all possible?

The idea is that when a DMT molecule gets absorbed in the duodenum it rather quickly encounters a MAO enzyme which binds the DMT molecule and makes it undergo a chemical reaction so that it's no longer psychoactive. The thing is that this chemical reaction can't be completely instantaneous but has to take a short amount of time. During that time the MAO enzyme will be blocked and not able to bind a new DMT molecule making in principle DMT an MAOI, although a very weak one. I have read about people taking a couple of grams of DMT orally and not received any effect but mayby the threshold dose is somewhere in the range of tens of grams or even hundred of grams.

Does anybody here know of some experiment to determine oral DMT threshold dose? Have anybody here tried to consume a large dose of DMT without MAOI and got some effects? Could there be other problems with consuming large amounts of DMT orally, for example could it be toxic in large amounts?

I want to stress that this is only a thought experiment, I don't recommend anyone experimenting with taking large amounts of DMT and never intend to do it myself either.

I'm pretty sure you would vomit it up long before you felt anything significant, since even as little as a few hundred mg can cause a purge. In theory there is a finite amount of MAO, so you could potentially get some effects if you took enough. However, I think the main problem is that the absorption rate in the stomach is so slow that even if all of the MAO is busy, the DMT gets deactivated in the bloodstream faster than it can be absorbed, resulting in no net effect.

Sounds possibly unsafe to consume many grams of DMT. Maybe in such high amounts the DMT will also bind significantly or affect other enzymatic or receptor systems before it is metabolized, or maybe there are other unknown side effects. At the very least I can imagine some severe abdominal irritation.

Overloading the MAOs with an active compound to find the enzyme`s limit and compound safety in oneself is not something I`d recommend.

If what you want is effects without having to use MAOIs, why not use a different route of administration that bypasses first-pass metabolism? Like vaporized, anal or even (doing carefully etc) IV use?