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DMPEA is found in:
Lophophora wiliamsii (Lundström and Agurell, 1968a)
Trichocereus pachanoi in 0.005% - 0.0005% fresh cactus (Agurell 1969b)
Trichocereus peruvianus (Pardanani et al 1977)
Trichocereus werdermannianus (Lundström 1970a)
Echinocereus merkeri (Agurell et al 1969)
Pachycereus pecten-aboriginum (Bruhn and Lindgrenilosocereus maxonii (Pummangura et al 1977)
Islaya minor (Doetsch et al 1980)
Pereskia corrugata (Doetsch et al 1980)
Pereskia tampicana (Doetsch et al 1980)
Pereskiopsis scardens (Doetsch et al 1980)
Opuntia spinosior (Pardanani et al 1978 )
Cylindropuntia spp. (Meyer et al 1980)
Opuntia acanthocarpa - Main Alkaloid (shulgin 2011)
Opuntia echinocarpa - Main Alkaloid (shulgin 2011)
Polaskia chende - Main Alkaloid (shulgin 2011)
Pterocereus foetidus - Main Alkaloid (shulgin 2011)
Pterocereus gaumeri - Main Alkaloid (shulgin 2011)
Stenocereus beneckei - Main Alkaloid (shulgin 2011)
Stenocereus stelllatus - Main Alkaloid (shulgin 2011)
Stenocereus treleasei - Main Alkaloid (shulgin 2011)
Neoraimondia arequipensis - Minor Alkaloid under 0.01% (shulgin 2011)
Opuntia exaltata - Minor Alkaloid under 0.01% (shulgin 2011)
Opuntia ramosissima - Minor Alkaloid under 0.01% (shulgin 2011)
It is potentially a bioprecursor to mescaline (shulgin 2011)
It was also found in legume Desmodium tiliaefolium (Ghosal and Srivastava 1973a)
and reported in Acacia rigidula (Clement et al 1998 )
It was reported in the urine of schizophrenic patients (15 out of 19) but absent in the urine of normal subjects (Friedhoff and Van Winkle 1962). The use of isotopically labeled material indicated endogenous source of it in urine of schizophrenic patients (Friedhoff and Van Winkle 1962, 1967). Again it was found in urine of schizophrenic patients but not normal (Sen and McGeer 1964), or it was found also in normal subjects but less often than schizophrenics (Takesada et al 1963). Free and conjugated DMPEA appeared in urine of both schizophrenics and normal subjects at comparable levels (Siegel and Tefft, 1971).
It appears urinary DMPEA had tea as its origin (Stabenau et al 1970)
DMPEA, bufotenine and N-Methylepinephrine were observed in th eurine of psychotic children (Perry, 1963). DMPEA was not present in the urine of schizophrenic patients who had controlled diets and were off of medication (Perry et al 1964).
Synthesis, TLC, GC, UV and other properties (Ono et al 1976)
C-NMR spectra (Bailew and Legault 1983)
Mass Spectra of this and other 54 phenetylamines (Kolliker and Oehme 2004)
C14 labeled DMPEA was used to explore the biosynthesis of mescaline in Lophophora williamsii (Lundström and Agurell 1968b). Injection of C14 labelled 3,4,5-DESMETHYL into L. williamsii led to biosynthesis of mescaline whereas injection of C14 DMPEA gave a higher yield, suggesting dopamine might be an intermediate, giving rise to DMPEA through O-Methylation (Paul et al 1969). Radiolabeled dopamine was 3-O-methylated to give GEA in Trichocereus pachanoi, which lead to both DMPEA and mescaline (Lundström 1970a).
Metabolism of mescaline and DMPEA were compared in eight human subjects (Friedhoff and Hollister 1966). Metabolism of DMPEA in rats produced 3,4-dimethoxy-phenylacetic acid (77%), N-acetyl-DMPEA, dimethoxy and 4-demethylated phenylethanols and there was also 4-demethylation (as N-Acetylamine and the glucoronide) (Schweitzer and Friedhoff, 1966). In humans, with parenterally administered radiolabeled DMPEA, 75% excreted as 3,4-dimethoxyphenylacetic acid and 20% was excreted unchanged (Hempel et al 1982)
DMPEA was a common substrate for both types of MAO (Suzuki et al 1980)
Serotonin receptor site affinity was determined Glennon et al 1980a)
In human subjects, DMPEA shows NO activity at oral doses that are active for mescaline. This is ascribed to its relative complete conversion to an acid by oxidative deamination. Acute oral administration of 550mg produced no psychedelic effects, nor did the consumption of 900mg over the course of seven days (Shulgin et al 1966). Active oral dose is certainly greater than 1000mg, duration unknown (Shulgin and Shulgin 1991).
DMPEA, as well as its analogues, are NOT scheduled compounds under federal USA drug law or under District of Columbia or any state laws (Shulgin 2011)
Notice the methoxy groups can be in different positions, so DMPEA can be one of several isomers, though usually it reffers to 3,4-DMPEA, which AFAIK is the only one found naturally occuring so far. Some isomers example:
2,3-DMPEA
http://isomerdesign.com/PiHKAL/C/pk448.pngCAS (3166-89-0 HCl salt, 64610-31-7 Sulfate, 3213-29-4 Freebase)
M/Z 181.1103
Freebase bp 138c/8mm (buck, 1932)
Synthesis, TLC, GC, UV and other properties (Ono et al 1976)
C-NMR spectra (Bailew and Legault 1983)
Mass Spectra of this and other 54 phenetylamines (Kolliker and Oehme 2004)
Effect on rat brain enzymes (Clark et al 1956)
Effect of ring methoxy groups on oxidative deamination (Clark et al 1965)
Human activity unknown (shulgin 2011)
Effect of ring methoxy groups on oxidative deamination (Clark et al 1965)
2,4-DMPEA
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CAS (2039-55-6 HCl salt, 64610-32-8 Bisulfate, 15806-29-8 Freebase)
M/Z 181.1103
Freebase bp 140c/1mm Hg (Kondo et al 192
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or 100-110c (Weinstock 1987)
Synthesis, TLC, GC, UV and other properties (Ono et al 1976)
C-NMR spectra (Bailew and Legault 1983)
Mass Spectra of this and other 54 phenetylamines (Kolliker and Oehme 2004)
Binding to 5HT1c and 5HT2 receptors studied (Glennon et al 1992)
Effect of ring methoxy groups on oxidative deamination (Clark et al 1965)
2,6-DMPEA
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M/Z 181.1103
Synthesis, TLC, GC, UV and other properties (Ono et al 1976)
C-NMR spectra (Bailew and Legault 1983)
Mass Spectra of this and other 54 phenetylamines (Kolliker and Oehme 2004)
Binding to 5HT1c and 5HT2 receptors studied (Glennon et al 1992)
Effect of ring methoxy groups on oxidative deamination (Clark et al 1965)
3,5-DMPEA
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