Does anyone have any experience with this?

More specifically, has anyone tried combining it with an MAOI?

Yes, my wife and I have used this compound extensivly.

I would highly suggest NOT combining with an MAOI. It has not been proven to be safe in any way.

5-MEO-MIPT is highly unpredictable in its effects. It can become extremly jittery at times and too much gets highly unpleasant.

5-10mgs is a very gentle non-visual physical experience
10-15 minor visuals, strong physical euphoria, slight mind alteration
18+ things get highly visual, time becomes very elastic, heart beat rises, bp goes up, things can get very bizzare.

The above is only the dosages my wife and I have found to be pleasant, others find they need a lot more, or a LOT less.

My wife and I usually do between 16-20mgs. An MAOI in my opinion could be asking for trouble. I would personally be concerned with a hypertensive crisis with that combo.

5-MEO-MIPT really doesn't need anything to boost it, it's quite powerful on it's own.

If you REALLY want something to boost it, use any of the 4 subtituted tryptamines (4-ho-dmt included) The combination of 5 subtituted and 4 substituted tryptamines seems to be VERY powerful even at low doses, be careful if you do this.

The second option is to plug it. You only need about 1/2 the dosage and believe me, it kicks in within 2 minutes this way. You can also snort it if you really want to, also 1/2 the doseage and get ready for a fast comeup.

Thanks for the info. SWIM will refrain from combining it with an MAOI since this is his first time trying 5meomipt. He was just curious- there is little to no info available on such topics.

What bout smoking spice while on 5-meo-mipt? Did SWIY ever try that?

Keep in mind that SWIM will be dosing in the 5-10mg range (for the 5meo)

SWIM took 7mg orally of 5-meo-mipt at a bluetech show last night. So far it was his least favorite RC. Very slight visual distortions, but mostly just euphoria that most closely resembled MDMA, but also felt like DMT at times.

Do you know of any major negative side effects?

5-meo-mipt is one of my favorite social drugs (next to mdma of course).
I typically dose 10mg which leaves me stimulated , happy , sociable and with a pleasant tingly body high.
I have used this chem quite a bit and there are relatively few side effects that I have noticed although dosing too much can leave one feeling fried the next day and it is almost sure to keep you awake all night with residual stimulation.