MAOI's have been given by doctors to people to treat depression. So can one take harmalas daily as an antidepressant?
And how much would one need to take daily? Is it possible to take a dose that wouldn't have any psychoactive effects but would have effects on depression?

Anyone here tried that out? And how would that effect anxiety?

i am interested to know more aswell

try searching a bit, theres been many many discussions on this :]

i just microdosed on some mimohuasca , and i do feel good

I had some situational depression and anxiety for years due to another crippling illness, but it went away after going Paleo (with a lot of wild fish + kefir). You might want to try that diet for a month or so, and see how you do, instead of taking alkanoids daily. Give your brain the right food to heal, rather than masking the issue. Wheat/gluten proved to be the No 1 culprit for me btw. Just sayin'.

I do have quite a healthy diet and have found out that there are things I should avoid.
Sugar and sweets one of the worst for me. And all deep fried crap food. Just makes me sick. Very lethargic and headaches and stuff.

I just lack self control to follow a very strict diet. But I sure need to be careful what I put into myself

I have tried using low-dose harmalas (approximately .5 g rue) for my social anxiety and depression. Combined with Rhodiola rosea (a weak irreversible MAOI) it gave me some noticeable results after a few days, but not so much the harmalas alone. For me it proved impractical though due to the short half-life of the harmaline, forcing me to redose several times a day to keep the magic going.

Irreversible MAOIs such as Nardil (Phenelzine), Marplan (Isocarboxazid) and Parnate (Tranylcypromine) have been said to be the "gold standard" for treating depression and social anxiety in particular. RIMAs such as Moclobemide have proven to be less effective, or with a similar success rate as SSRIs/SNRIs.

I've read at least one report of Harmaline and Selegiline (a selective MAO-B inhibitor) being a pretty effective combo for a guy suffering from social anxiety disorder, but I'm no doctor so I can't say if such a combination would be a safe one.

It should be noted that taking irreversible MAOIs requires one to follow a strict diet to avoid foods high in monoamine precursors or compounds as this can lead to a hypertensive crisis.

Caution: I have an insanely high tolerance to harmalas and DMT. The doses that I take as 'microdose' are enough to make others hallucinate. These doses are bad indicators for microdosages.

I have experimented with taking microdoses of harmalas daily to see how it influenced me. I have drunk as much as 1g of rue tea a day for a week and had significant improvement in mood. A single dose would be sufficient to keep my going for the day. During that period I received several compliments on my bright look and I smiled a lot.

More recently I'm experimenting with microdosing capped harmala hcl extracted from rue. I oversalted my harmalas a bit so I estimated that my caps contain around 130 to 150mg of harmalas. If I take one in the morning and another one somewhere around 3 in the afternoon I have an amazing day. I feel happy, negative emotions are present but aren't in charge. I am capable of reflecting on the emotion and letting it go.

I've also dosed higher during bicycle rides for enhanced visual acuity but anything above 250mg is uncomfortable on the stomach. These high dose bicycle rides sometimes act as a reset: if I do them for three days in a row and take two to three caps spread out over 2 to 3 hours there won't be a purge and I will experience moodlifting effects ranging from severals days to two weeks or more. However, it's very uncomfortable on the stomach and sometimes I think it's better to dose them at all once and purge the negative emotions.

I would personally rather take harmalas as an antidepressant than any SSRIs, irreversible MAOIs, tricyclics or the like. Harmalas have better researched long term effects compared to most of the antidepressants sold by pharmaceutical companies. Harmalas are known to increase 5-HT receptor density in certain brain areas.

I'm also quite sure there are people who have little or no benefit from harmalas. Please do remember that harmalas, just like any other antidepressant, are just a crutch. The best solution to depression is to deal with the causes of it through therapy, counselling or entheogen use (or a mix).

I haven't felt much or any depression for around 12 years but last winter was quite hard for me. My depression is seasonal so I'm fine now in summer. But I want to be ready if I start to descent next winter. I'll be quite busy and I need to be focused and keep my spirit up for upcoming projects.
I have around 5gr. of rue extracted freebase. I will experiment with that.

Thank you for your reply's.