So I'm about to begin initiating my friend into the world of DMT, an older dude, about 56. He takes Prozac (I'm going to get him off that poison in time ) for road rage (retarded, right? ) and no other medication. I know Prozac is an SSRI, and I'm wanting to start his journey with my changa, as I've introduced a few people to DMT now, changa seems to make a gentle introduction to the glorious madness.

Would this be dangerous? The changa mix is 1 gram mullien, 1 gram plain caapi leaf, and 2 grams magic pixie dust. Would the caapi leaf hurt him? I could make him a batch of boring ole mullien and DMT alone, but the dash of caapi really makes the smoke special (though, I've never smoked changa without caapi, so I guess I really don't know if it makes that big a difference. )

I've got a lot of work to do with this guy, and eventually, when he's well off the Prozac, I will take him down Pharma Lane. Basically, I don't want to scare him away with pure freebase, though, come to think of it, why would it scare anyone away? It's freakin' amazing!


Ohh! Aside: What do you fine folks think of my plan: To get my friend off Prozac, I'm going to try and convince him that Syrian Rue acts as a natural anti-depressant, and that a cup of syrian rue tea will do more good for him than all the Prozac in the world.

Never, ever mix SSRI and MAOI! Safety first!

Also if people stop using prozac it takes some time before the prozac is out of the system and safe again to use a MAOI. I have heard between two and six weeks to completely get rid of the prozac in ones system. So even if you get this person off the prozac, it will take some time before you can give this person Changa.

Hopefully Corpus Callosum can chime in on this one too?


Kind regards,

The Traveler

SSRIs and oral MAOIs/RIMAs are a big no-no; I doubt that the big pharma companys have investigated the interaction of vaporised RIMAs (or if they have theyve kept the results very quiet ) but I would advise avoiding this combination.Most SSRIs require a two week interval between the last dose taken and the ingestion of MAOIs/RIMAs but Prozac requires a six week wash-out period.

I think a health conscious approach should be taken but it must be said that some have smoked changa with compounds such as MDMA or opiates and not had adverse effects.


I would love to know what the differences are in terms of metabolism of smoked/vaporised RIMAs compared with the oral route.Until we have firm data on the differences I think its best to err on the side of caution.

Thanks, gents. Safety first, always; he's gets mullien & DMT only.

Long live the Nexus!

Tetra, also keep in mind that SSRIs and especially chronic use of such medicine may "blunt" the effects of "classic psychedelics". I do not know if the same holds true for DMT , but the possible downregulation of serotonin receptors coupled with increased serotonin in the synaptic cleft might leave "fewer places" for DMT to bind.

So, in other words if he wishes to try it go for a normal/introductory dose but do not be amazed if it appears "small". Later, the dosage can be incresed but be cautious at first.

Does anyone here have experience with SSRIs coadministered with DMT or if DMT has lessened effects after chronic SSRI use? I have heard -and could be possible- that chronic SSRI users may be less responsive even after the "washout" period because of neuroadaptations.

I'm permanently on a low maintenance dose of Prozac due to several depressive episodes I had more then a decade ago as a young adult. When I tried vaporized DMT, it seemed my doses fell into a pretty much "normal" range (i.e. 10-20mg light, 30mg moderate, 50mg accidental dose due to leftover spice in the smoking device caused a very scary trip accompanied by a partial memory blackout of the trip).

I did also have a chance to try the same batch of mushrooms once both while on Prozac and after having not taken it for over a month. Subjectively, I would say the Prozac weakened my trips by about 30% (i.e. I had to take about 30% more dried mushrooms to get the same effect when on Prozac), but it did not seem to change the character of the trips.

..Changa usually means there is caapi extract or some kind of beta carboline present..

Harmine and Prozac are a very dangerous combination, potentially lethal at high harmine levels..!
other SSRIs may be less dangerous in combination (such as moclombomine)
.

moclobemide is an MAOI and not an SSRI. Moclo will potentiate DMT like harmine

Hey everyone,

This is a very pertinent topic to me, as well. I am aware that there are very serious dangers (i.e. serotonin syndrome) associated with combining SSRIs and MAOIs. However, is it safe to combine moderate/"breakthrough" doses of DMT (or any psychedelic tryptamine that acts on 5HT receptors) with an SSRI?

Although I have done this in the past without any ill effects whatsoever, I have never been entirely clear on the question.