I bought some rue and I want to extract the Harmalas to add it to my changa. I couldn't really find why to separate these two substances but I read somehwere that one makes you more stoned but only if ingested.

1) So does the separation make sense?

Old post but who knows...

The only way to know what's best for you... Is to experiment

For changa though, I don't really see the need to go through the "trouble", but that's just me...

first of all there is no one substance called harmala. It is harmine and harmaline.

They each precipitate at a different PH. This is how they are seperated.

I'd like to seperate harmaline and harmine eventually, just to see if the differences are that noticeable. I'm just too lazy at the moment

As already pointed out you have harmine, harmaline and THH which are all harmalas. With the two common sources for harmalas (caapi and rue) only caapi contains THH.

Of these harmalas, harmaline is the strongest by weight and people who take it find that it gives more body load.


Kind regards,

The Traveler

I've dosed DMT fumarate both with harmine/harmaline (extracted from rue) and only with harmine HCl. Comparatively, the experience with harmine felt more gentle to the stomach, and after ingesting similar amounts of food in a similar timing before dosing, I did not have to purge... but don't take that as a rule.

Harmine required a higher dose for inhibition, though. Which agrees with data reporting a higher efficiency of harmaline inhibiting MAO-A per weight unit.

I have performed this isolation and personally I didn't notice much of a difference between one or the other. Don't hear me out wrong they both have different biological effects to certain degrees. Though my brain/body isn't capable of being aware of the ratio of how inhibited my MAOI-B is verses my MAOI-A and so forth. The difference was so indistinguishable that I hardly even remember even trying it to be honest. The procedure I used which is a published procedure(reference eludes me now but it is out there). It consisted of adding concentrated ammonia to the solids at I believe 55*C just until one of the compounds began to precipitate, then quickly filtering while hot. I obtained on many occassions different colors of flourescence at similar concentrations of both solutions. At the time this was the best form of analysis I had available and it satisfied my curiosities.

An interesting experience for the OP might be to extract from both rue and caapi and test the different changas.
I, for one, would be very curious about the THH influence.
I have both kinds of changa right here, but have yet to try the one I just made with harmalas from caapi instead of rue.