well yea of course adding in the tryptamines will help even more. i've done the weekly full dose thing, and when to that i add daily harmalas/caapi/rue the results are better than either on their own

Yeah of course it is still good on it's own and I microdosed caapi and rue daily for a year so I was obviously liking it for some time..I dont feel like I need to do that any longer though but weekly use of a tryptamine with some beta carbolines helps keep my mind on track..even if its just changa or some snuffed DMT and harmine.

So i'm on day two now and start noticing results. I forgot how caapi is able to make you feel real minty inside! This inner cooling effect really is something. It's to early to draw a conclusion, but so far i've noticed beneficial effects. I had leaf during the day because it doesn't tire me so much and vine in the evening. Waking up slightly more groggy, but we'll see. Next couple of days will be vine only.

I like to smoke some Caapi leaf with some of the S. tortuosum mentioned earlier along with some Mucuna pruriens mix. Eating a Griffonia simplicifolia seed before bed is fine (safe 5-HTP).

Griffonia tea after green tea/EGCG is mighty fine alone; but combined with the above smoke is a real delight.

Kanna (Sceletium tortuosum) is quite potent even by itself. It is an SSRI so take care with it; you wouldn't mix it with other SSRI's like St. John's Wort.

That said I've had good luck with a common "Good Mood Tonic" that contains extracts of:

Well, MAOIs and SSRIs are great - if you like serotonine syndrome and death. Why would you even risk taking caapi with kanna? I appreciate you sharing ideas but this seems like a really bad idea.

Ontopic: I don't know, i feel as if i'm coming down from a psychedelic with this not so pleasant vibration inside that feels a bit like a flu recovery. Mental effects are ok, less anxiety i have noticed. But the stoning effect is really not so enjoyable. I won't take any vine tonight because i woke up in the middle of the night, feeling really bad and dizzy. So far, i've had better results with the leaf alone and it tastes fantastic.

"I won't take any vine tonight because i woke up in the middle of the night, feeling really bad and dizzy"

That happened me to often when I was microdosing harmalas every night..though I didnt just feel bad or dizzy I would wake up tripping unable to get to sleep..which left me tired and irritable the next day. I did not always wake up dizzy or anything though sometimes just tripping feeling okay but just too awake to sleep..though other times I would wake up with nauseating tracers and stuff.

Dose like that for a year reality can get very very weird man. It's like being psychic or something at times with a serious lack of sleep lol.

Honestly, i think the answer to depression is the odd ayahuasca session, and changing your behaviour. I dont think microdosing is the answer, you want a peak experience to get out of that trough, then youll need good diet and regular intense exercise to help you to feel great,etc.

Some interesting links:

Depression:
http://www.sciencedirect...le/pii/S0361923009003049
http://www.sciencedirect...le/pii/S0278584609002498
http://link.springer.com...00702-010-0451-2?LI=true
http://www.hindawi.com/j.../oximed/2010/735923/abs/

Anti-Cancer:
http://www.sciencedirect...le/pii/S1499387211601021
http://www.sciencedirect...le/pii/S0014299910008903
http://europepmc.org/abstract/MED/21967457
http://onlinelibrary.wil...0.1002/ptr.2860/abstract
http://www.hindawi.com/j...ls/bmri/2013/258095/abs/
http://link.springer.com...0.1007/s11060-012-1034-x
http://www.plosone.org/a...1%2Fjournal.pone.0052162
http://www.biomedcentral...t/pdf/1749-8546-6-11.pdf

Neuro-Degenerative Disorders
http://www.akademiai.com/content/q0t1850m48119131/
http://www.sciencedirect...le/pii/S0091305703001291
http://www.hindawi.com/j...ls/chem/2013/717232/abs/
http://europepmc.org/abstract/MED/19784581
http://www.sciencedirect...le/pii/S0028390810002868
http://pubs.acs.org/doi/abs/10.1021/jm1000024
http://www.plosone.org/a...1%2Fjournal.pone.0019264

Addiction Treatment:
http://jop.sagepub.com/content/27/1/98.short
http://www.sciencedirect...le/pii/S0304394012010130
http://www.sciencedirect...le/pii/S0278584612001364

Other:
http://www.sciencedirect...le/pii/S0300908412004324
http://www.lifesciencegl...bwi/article/view/217/pdf

Short summary of current research on harmine: http://apjtb.com/zz/20128/14.pdf

Those are all recents studies (last 4 years) on the therapeutic uses of harmala alkaloids. They are getting a lot of attention, and they seem to have a strong antidepressive effect. Take the time to read through, they are all very interesting.

Cheers

Well, i don't really need harmalas for that
But it is really psychedelic and differs from other mood altering substances such as cacao in that way. I have noticed an increase in "ideas" or "messages" if you will and some of them are similiar to the messages i get on full brews. For me, they are often about how the body relates to the "soul" or the psyche if you will. About our energy fields and so forth.
For instance, i was meditating and was shown the picture of a human egg about to be fertilized by a sperm. The sperm represented thought and i had to cut it off to stay focused on my breathing...let it wash away so not to have it grown into a "thought baby" of some kind. I have lowered my dose today and so far i'm feeling better.




Why not both if microdoses and small doses provide the guidance you need to follow through with everything?

@Toloache
Great post! I appreciate the contribution...
It's a bit discouraging though, that they have tested anti-depressant effects on rats using a very high dosage. They translate to 900mg harmine for a human around 70-80kg. That seems like an aweful lot. With these studies you always have to keep in mind if they're really relevant. You might be able to prove that inhaling the fecal matter from your colleague farting is unhealthy for your sinus, but does it really make you sick (apart from the smell?) ...- probably not.

Excuse the weird example. I'm just too good at that

Keep in mind there is sort of a conversion from rat to human, if i am not mistaken human dosage is 1/6 (/6,2) of that of rat.. So in this case the dosage of 10 to 30 mg/kg for rat would be converted to 1,6 to 4,8mg/kg for human (so from 112 to 336 mg for the average 70 kg man).

This paper talk about animal to human conversion in great detail:

http://www.fda.gov/downl.../Guidances/UCM078932.pdf

It's a very strong wakefulness promoter and it should be treated in a similar fashion to caffeine. Its mode of action seems to be different. Maybe it inhibits melatonin in some way due to excess serotonin running around; either way it is very good for combatting sleep deprivation. But it can also *induce* sleep deprivation, which is why it's not a good idea to dose it late at night particularly through ROAs other than vaping alone.


Combined with L-tryptophan or even just melatonin, the wakefulness promotion is inhibited it appears. However I don't think it would be wise to dose tryptophan too regularly while under MAO inhibition.

Unlike caffeine it doesn't force you awake at your own expense but it does require you to treat sleep very differently. Sleep becomes something more of a choice than a necessity, which can lead to sleep deprivation if you fall out of your natural cycle due to being unaware of your dosage pattern. It behaves most similarly to Modafinil in my experience. On Modafinil you can get to sleep just fine unlike caffeine but there is a good chance you won't want to! As a result the cumulative effects of sleep deprivation can take you out.



I notice this to be a distinct effect of harmalas when in the system for a long enough period of time (i.e. dosed orally). You will find insights/new angles of perception continuously flooding your mind every few minutes or hours. Very good for mindfulness and exceedingly psychedelic. They go as fast as they come but they just don't stop coming.


Thanks for the links Toloache

Interestingly: In further studies to seed of P. nigellastrum Bunge, activity-guided fractionation led to the isolation of two new alkaloids nigellastrine I (9) and nigellastrine II (10), and along with eight known alkaloids, vasicinone (1), vasicine (2), harmine (3), deoxyvasicinone (4), deoxyvasicine (5), harmaline (6), harmol (7), harman (, in which harmol and harman were first isolated from species P. nigellastrum Bunge. As active constituents, all compounds showed good inhibitory activities against AChE.
http://europepmc.org/abstract/MED/19784581


Wonder if this could lend any clue to the makeup of Harmala Red? How would we isolate these two alkaloids?

This for me says it all. And of course entheogens are very much included in what gives me a sense of wonder and reverence for the universe.