Hello, Mustelid here. I've suffered chronic debilitating migraines, and tried just about everything from $100 per pill triptan medications, vitamins, herbs, meditation, and suicide attempts. I can't afford the official medicines and opiates don't work, they just delay the pain and lead one down the hell path of lowered endorphin levels, rebound migraines, tolerance, and physical dependance.

If you have never experienced a migraine, they're not normal headaches, they trigger nausea and are way more painful then stubbing a toe or even dental pain.

I recently tried smoking DMT for migraine relief.

The closed eye screensavers are beautiful and the pain goes away. Unlike the official legal triptan remedies I don't suffer from tanked serotonin levels for the next few days, which often led to rebound migraines. It isn't just narcotics that can cause rebound problems.

DMT leaves me clear-headed in 20 or so minutes, and with no serotonin crash later, it doesn't seem to be triggering rebound pain.

I can't thank everyone enough for spreading knowledge that can literally save lives.

That's awesome Mustelid! I suffer from severe tension headaches which I thought initially were migraines (but fortunately they weren't and ibuprofen sorts me right out). So I relate to some extent.

It's interesting that smoking DMT solves the problem for you. What kind of dosage do you find best? I ask because I'm keeping a list of potential DMT research topics and this could possibly fit the bill.

Anycase, greetings from another newcomer.

Interesting. I think soon I will test myself for migraines. I just had, what I think was a migraine, one last night and couldn't eat, drink, have noise or light affect me.

It's insane! I took two tests and I tested positive for both. I get these 2-4 times a week.. I can't deal with it. Feels great to wake up and be free from it though!

I am glad DMT works well for you!

Welcome to the nexus mustelid! Glad you could find some kind of relief from your migraines with dmt. I wish it was that easy for me. I have tried smoking dmt at the onset of a migraine to find no relief (for me I was pretty desperate and looking back it was actually pretty risky to not know what was gonna happen). I've tried holding chewed up mushrooms under my tongue which i did feel like that worked a little better than the dmt.

This is all after going to neurologist and using the prescribed tryptans, beta blockers, ant-epileptics, etc... What the psychedelics have allowed for me to do is understand the things in my life that stress me out that comtribute to my increased migraine frequency. The one thing looking back that I didn't consider was my drinking, I think I was drinking so much that I had a build of toxins that was a major contributor to not only my migraines but also my overall poor health.

The 5ht2a sertogenic neruoreceptors such as triptamines and tryptans target the same binding site for the same response, vasoconstriction. A migraine is caused by a bulge in a blood vessel in the brain causing infalamation in the areas that cause the symptoms of nausea, numbness, vision impairdness, etc... The inflammation is what causes the pain from the bulge. For me once I get a migraine it is there to stay so smoking dmt won't help much less majority of the tryptans. I need something that gets into the system as fast as possible (the longer it takes the less likely it'll work, once pain sets in forget it -won't work) the nose sprays were working for me for a while then they started to not work then I came upon an injection pen called serovil. Works by subcutaneously injecting the medicine with a blast of air...stings like a bitch but if i can get to it in time it is well worth it (but very expensive).

I've turned my lifestyle around with the aid of psychedelics but there is still much work to be done and I hope you can find some kinda relief with this miserable illness as there is a light at the end of the tunne. I see migraines as a forced mediation as I can never sleep and are akways filled with dark thoughts often suicidal in nature and when things get too intense the purge does bring relief sometimes enough to fall asleep. Again good luck and welcome to the nexus!

Mustelid, as a fellow migraine sufferer, you have my utmost sympathy. Although I don't get them nearly as badly and frequently as some do, it's still a nightmare. I used to get them every 3-9 months from the age of 15. The weird thing was there was a period of five whole years where I had none. I thought I was permanently cured until they came back a couple of years ago, with the same regularity as before.

I'm intrigued to learn that DMT offers you relief. Sounds like it actually aborts the migraine altogether, rather then just masking the pain. I find this interesting, since many migraine medications are actually indoles, just like DMT is. I have no means of obtaining pure freebase DMT to smoke, but I wonder if the oral route with harmalas would work fast enough. 45 minutes might be too long to wait.

Thanks everyone for the welcomes.

Khronos, I worked cautiously up to 15mg. I'm not after a breakthrough experience, if it accidentally happens, then that's ok, I'll just have to deal with it, no other choice really, but in my case I'm using the substance as medical therapy and not psychonautic exploration.

Kobranek, I hear you on the drinking. I experimented with smoking and drinking as a teenager and gave up on both due to finding that they both exacerbated migraines greatly. Cannabis gives me relief for about an hour, then they come back and no amount of smoking will help at that point. It has been good waiting for knock-out dosages of cold remedies to kick in though, which has been my standard way of dealing with the pain when it becomes too excruciating. This isn't good for being productive that or the next day however!

I found other triggers, and have spend my life experimenting with dropping various things out of my diet, but I feel at this point that I've found all the dietary triggers that I am going to find, and they still come.


I have had a couple of experiences with LSD and psilocybe cyanescens and cubensis years ago as a young adult, but it never occurred to me that there might be migraine relief in these substances. I do plan on trying cubensis for migraine relief, even though oral isn't as fast acting as smoked, I have read some reports that indicate that powdered dried mushrooms in fluid can have effects start in under 15 minutes as well as reports from some people that psilocybin works better then DMT for migraine relief and/or prophylaxis.

Howdy, welcome!

I thought you might be interested in reading this thread:

migranes

A warm welcome also from my side. Good to read that DMT effectively heals your migraine. I´ve recently seen a documentary, where it was shown, that LSD acutally helps people suffering from cluster headache. Too bad research isn´t ongoin as it could...
I wish you all the best with the new medicine.

Welcome to the Nexus!!


That is great to hear that you found relief from dmt for your migranes. I have never had any migranes, but I feel for you.

Hi Mustelid

I have been fortunate enough not to have chronic migraines. However when I had Lymes Disease (before I knew about it and sought treatment) I experienced them somewhat frequently.

I by no means want to give you any more stress than you already have, but often times migraines are a symptom of an underlying medical problem. Just something to keep in mind. Have you gotten a blood test or MRI or anything?

Also, not that it's any of my business, but is there a reason you are trying to avoid breaking through?

Anyways I hope your migraines stay away, as I can recall how annoying and painful they could be.

Wearepeople, I'm glad you managed to overcome your migraines. I agree that stress can be a big trigger, and relaxation can help.

I read the thread you linked to, that kambo that was discussed sounded interesting, though it seems to me something that should only be administered by an experienced practitioner!

Suburban Tea, thanks for looking out. I have gone the route of Western medicine, particularly back when I had a career and medical insurance. I've had MRIs, x-rays, blood tests, lumbar punctures. I've seen neurologists, and have been prescribed sinus medication, beta-blockers, ssris, triptans, and narcotics.

The good news is they couldn't find something growing in my brain that wasn't supposed to be there, or any health condition worse than chronic sinusitus. The bad news, is that none of the prophylactics worked at all, and none of the abort medications worked very well.

I'm not trying for breakthrough as at this point in my life, I don't feel I need the distraction of huge changes in perception or having my consciousness blown past the bounds any of my experiences. Not to say that I never will, in the past other hallucinogens came when I needed their teachings. My smoking technique isn't particularly good as I'm new at this, so as it is, I haven't vaporized DMT unsupervised just in case, so I don't fear a breakthrough.

The hope that I get from DMT actually working has made me a much happier person, it's a very huge deal to me, and I plan on soon trying mushrooms as psilocybin seems to hold the promise of a semi-long-term prophylaxis which would be even better then a good abortive treatment. I remember from my past that psilocybe mushrooms were quite a nice experience, even the level 4 I had on my first trip. If one thing doesn't work I can try others, if mushrooms don't work, I could try to make my way down to South-America someday to seek a shaman and see if they can do better then the clinics and hospitals up here.

Hi Mustelid. Sorry to rehash your old intro, but I hope you'll share a little more on your dosage for aborting migraines. I also suffer from them, usually 1- 3 a month. Sumatriptan works well for me but is quite expensive without health insurance, so I'm hopeful DMT will also work due to the chemical similarities.

I know you've said very small (light OEV) doses work best and saw you say you were using about 15 mg, but it looked like you were just beginning to experiment with DMT for migraines and CH. Are you still working with about the same amounts for relief? Have you tried low oral doses with RIMA, or just smoked?

Thanks so much for your input!!

I missed this when it was first posted, but I've seen some of your posts Mustelid. Maybe it's just me, but there seems to be more and more people turning to tryptamines and other natural treatments for migraines and cluster headaches. I'm also a sufferer and have mushrooms to thank for keeping my symptoms at bay.

I still have yet to attempt to use DMT as a method to treat a migraine or cluster attack. I simply haven't allowed myself to suffer through one for a few years now Lately I've been wanting to take a break from mushrooms for a while and have been thinking about trying DMT as my primary treatment method. I smoke Salvia regularly as well, and have aborted small headaches with it in the past.

I think DMT (at least in vaped form) might work just as effectively as an oral mushroom dose, but might have a shorter period of action. One mushroom dose a month compared to two or three DMT doses. Just a guess, I could be wrong.