A friend was discussing other ROA for mescaline which led to the vaporizing mescaline. It was done about when the first dose should have kicked in so any increase in effects at that time may not be a consequence of vaporizing.

Tryptamines as a rule are more active via inhalation of freebase vapor than orally or intranasally, and this proved to be the case for bufotenine as well. In five bioassays, I tested increasing doses of inhaled, vaporized bufotenine free-base. BV-11 through BV-V involved inhalation of 2, 4, 6 and 8 mg bufotenine (0.03-0.11 mg/kg), respectively. All doses were decidedly psychoactive, increasing in potency proportional to dosage, with roughly the same pharmacodynamics save time of onset, which decreased in proportion to increased dosage (45, 35, 25 and 18 seconds, respectively). The first clear signal (acouasm) was at two minutes; peaks were attained at four to five minutes, unmistakable attenuation by seven to nine minutes, with diminishing effects evident for a full hour. In BV-11 through BV-IV, psychoptic effects were limited to that low-light, shimmery "magical varnish" over the world not evident in darkness and attended by synaesthetic psithurism; while in BV-V (8 mg), at seven to eight minutes there were also ring-like, swirling, colored patterns with eyes closed; visible, albeit fainter, with eyes opened in low light.