I am starting to microdose harmalas extracted from rue before sleep and quite enjoy the effect , it seems to help a lot for dream recollection. I am just wondering if any of you have experienced any interactions while doing this with other chemicals (Mdxx, 2c-x...) if you skip the microdose on the day you are indulging in other experimentation. Do you think the harmalas kinda build up in your system with time and how long do you think one should refrain from dosing harmalas before taking other substances with known or not so researched possible interactions?

Harmalas and amphetamines are a big no-no. Could result in serotonin syndrome

Well I know you shouldn't mix both but I'm wondering about how microdosing harmalas can affect MAOI inhibition and for how long should one abstain from taking it before experimenting with (in my case) phenetylamines. I guess it's kind of an unexplored territory but maybe some of you have some experience with it.

I know Ice House has combined 2CB and Changa before with no problems. But certainly with the MDMA you are running a risk.

I have been smoking and or orally ingesting 100+mg of freebase harmalas (full spectrum from syrian rue) for about 8-9 months, almost every day. No noticeable food interactions.

I didn't have the opportunity to experiment with anything but cubensis or DMT in that time, but notice no 'hold-over' MAOI effect on off days of dosing the aforementioned tryptamines, e.g. no unusual tolerance or threshold dosage changes in that time.