How does toxicity show itself physically or mentally? Any ideas..

With phenethylamines I'm not so sure about toxicity in the brain, I'm sure destroyed neuron clusters could be a possibility at extremely high doses or repeated use of neurotoxic phenethylamines.

Physically, the extremely potent phenethylamines, bromo-dragonFLY and DOB come to mind, can cause vasoconstriction so severely that there have been cases where gangrene developed in the extremities. Necrosis has also been observed in bromo-dragonFLY overdoses. If I remember correctly the individual who had to have his fingers amputated following an overdose estimated around 10-20mg of bromo-dragonFLY, also suffered from acute liver failure and kidney damage. His hospital stay was just over two months if I remember correctly.

All of this occured from an overdose estimated at a little over ten to 20 times the effective dose of bromo-dragonFLY(800ug)

At doses 100 times the effective dose, deaths have been reported. In the Oklahoma deaths of two men, who mistakenly ingested bromo-dragonFLY, thinking it was 2C-E, suffered from severe seizures, internal bleeding, and fatal vasoconstriction.

With all this in mind, I think it would be safe to assume that extreme overdoses of the NBOMes could result in similar physical damage and symptoms comparable to the ones mentioned in the literature on DOB and bromo-dragonFLY disasters.

There have been reports of 25I causing seizures as well, but I've only seen them in news stories so their credibility should be questioned.

if bromo drsagonflys doseage is 800 ug and 25-i's is 550ug or so then surely mew should have experienced some of those toxic effects?

That would be the case, assuming that both of the compounds mechanism of action were identical, which they are not. There isn't much information on the mechanism of action of 25I at the moment, but its affinity to be an effective vasoconstrictor would make this compound extremely dangerous at doses above 5 milligrams, some individuals are more sensitive than others.

Just as a case of an extreme DOB overdose(50 to 100mg of material, which is roughly seventeen to thirty three times the max effective dose of 3 to 3.5 milligrams) where an individual required a leg amputation due to severe vasoconstriction, I think it would be safe to say that at the very least vasoconstriction, convulsions, and eventually gangrene would become a serious risk if one EFFECTIVELY ingested anything over 15mg of 25I.

I've read a report of a person who claimed he overdosed 25B-NBOMe with 30mg, who was fine after the experiment. I've also heard of complete physical disasters at dosages around 4-5 with 25B-NBOme, and was witness to a person who took ten milligrams, about an hour into their experience they started convulsing and not responding. They were treated at the hospital for a "suspected LSD overdose" and released two days after hospitalization.

Claiming to have taken 10-30mg of 25I, though most likely done ineffectively in the sense that most of the material was probably wasted, is extremely reckless, and users should not assume that these are safe dosages for these compounds.

I've taken 25I intranasally and bucally, at doses ranging from 1 to 3.5mg, and I honestly see no need to go above 3.5mg with this compound. It is a FULL BLOWN psychedelic at 2.5mg.

i agree. I had a full on psychedelic experience with 25-i on complexed blotters at 1.75mg's

I have also had a similar dose to mew of 25-i hcl via insufflation of the powder, silly i know but it didn't feel as strong as the 1.75mg doseage. Is 25-i better suited if dissolved in water then shot up yje nose do you know?

in its hcl form its best dissolved into distilled water and insufflated via precision atomizer, much like a metered asthma medicine device or a really really exact nose spray.

you can safely dillute your dosage a bit more and use more than one spray to ensure that you build up to your desired dose rather than having it concentrated enough to where you migh accidentally dose too high by mistake

thanks mew. Was my roa i.e insufflating the bare powder not a good method of ingestion? doesnt absorb aswell etc?

Another question im hoping someone can answer. Does the chlorine in tap water destroy the nbome molecule?

i suspect if you didnt have a super clean nose some of it was lost to the boogers

yeah i was thinking that, thanks again mew