Ok so my friend took a huge hit of DMT 2 times and on 2 separate occasions holding the hits in and he had no effects. Is this even possible? I am so confused because he has smoked salvia and tripped balls several times. He seems to be immune to my DMT and my stuff is really potent, I mean one hitter quitter potent. Another friend of mine and I have smoked from the same batch and had great experiences. Now he is on Cloripramine and I'm wondering if that might have some interaction with the effects of DMT?

Does anyone else take the same medication or something of the same class of drug and have nil effects on DMT? It just amazes me because DMT is incredibly powerful and he literally reports feeling almost nothing from huge vaped rips. He's holding them in too for about 10+ seconds. He said it feels like it wants to open a door and do something but I know DMT is very good at blasting the door right off the hinges for everyone else including me

My friend is on a strong psychiatric ward injection and has no effects from my changa.. so maybe? I am aware that everyone has different tolerances but he cannot get an effect, no matter how hard we try. He has given up for now

I too experience zero effects from dmt. I am on no meds but I do get a feeling that it attempt to blast me off (a vibrating hum and some head pressure). Also 'your stuff' is the same as anyone's; dmt is dmt

No not all dmt is the same there are def ways that the substance can be hindered during the extraction ect, so strength can differ. Also Benzos will decrease the effects of all psychedelics...

This is incorrect...DMT is DMT.

There can be other substances pulled in addition to DMT that may change the subjective effects of ingesting the extraction, but that does not mean that the DMT is any different. Whether it's extracted or synthesized, a DMT molecule is identical to any other molecule of DMT.

That being said, anyone's "stuff" is not necessarily guaranteed to be the same as anyone else's "stuff".

truer words & what not... hell, my "stuff" from last time is not the same as my "stuff" from this time, & odds are the next batch will be a bit unique as well...

as for the OP, i dunno what to say even, i've got a friend who has the same problems, but for her it's all psychs... i've fed her shrooms twice (1 gram first time, 2.5 second time) lsd once (2 hits of paper that just destroyed every other individual who touched it) & i've attempted with dmt 3 times... she's never come close to getting off... just simply nothing works... it's the damndest thing i've seen in my life...

I said that incorrectly, I meant the material in which contains the molecule can differ in amount of other substance left behind from extraction ect.

..............My friend is on a strong psychiatric ward injection and has no effects from my changa.. so maybe? I am aware that everyone has different tolerances but he cannot get an effect, no matter how hard we try. He has given up for now ....

The effects of
psychiatric drugs are like [brain rape]...
The stuff they give a patient.. prevents the patient from even remembering their own dreams!
Many psychiatric drugs ,make a person like a living zombie...they block certain brain receptors...related to emotion and dreams...
aviod these drugs at any cost....
Ever see the movie ..[one flew over the cucus nest].. whith Jack Nicholson

That's weird because he's done shrooms before a couple times and felt strong effects. Although he is schizophrenic but I'm also mildly schizo myself. Just not medicated. The psych Meds he's on dont make him a zombie tho hes actually a really cool guy he's just really "out there"

I would be VERY wary of giving DMT to someone with psychiatric issues, and VERY VERY wary of giving it to someone on psychiatric medication, ESPECIALLY in the form of changa. MAOIs can have an interaction with a lot of prescription drugs, and that could be dangerous.

Looking up Cloripramine, it seems its a tricyclic ? Which I believe can be used to treat schizophrenic hallucinations, it wouldnt surprise me if that's not part of the issue here.

Mixing powerful anti-psychotic medications with highly potent psychedelics could be very dangerous, please be cautious people.

He might just be smoking the spice wrong. I had a friend who was hitting the spice pipe like weed for a year before he finally figured out how to hit it correctly. He never got any effects while I was blasting off into space..

You cant just torch spice and take a deep breath like bud, you slow heat it until its melted and when it starts smoking you breath it in veryyyyy slowly like a 10 second breath. Could that be the problem possibly?

Mm i agree, he is forced too take it once a month or gets arrested. He is not crazy at all but ended up in there due to shrooms which hes parents didnt know he was on. He will be off the medication asoon as he gets a job which I am taking him to hand out resumes. Strange story actually

He claims to have quite vivid dreams aswell. The zombie part matches up haha

Very strange.

I have reduced DMT effects, but still quite powerful. I take anti-psychotic meds, for depression and insomnia.

Strangely, I've taken LSD twice (100ug blotters) and experienced zero effects.