I've grown Calea z. for many years.

I think you're using way too much water. 5 times a day ?!

Try watering once every 2 or 3 days. The soil shouldn't be bone-dry, but it shouldn't be constantly saturated with water either.
Spraying the leaves isn't necessary.

Calea likes good drainage and poor soils. No fertilizer.

Calea z. usually does pretty well as a houseplant. It is more likely to have problems from too much attention, rather than too little.

Can you take another picture from a littler further back it's a little blury.

What kind of soil are you using how large is the pot?
What water do you use to water the plant with? I would use distilled or bottled water for the spray bottle. Do you check the ppm of your water source? I used to use tap water to water my vegetable plants and they would grow soooooooo slow and look terrible and i figured out it was the ppm and the ph of my tap water. My ppm = 600's My ph = 8-9 conclusion = horrible dying plants. I'm sure you know this already but you need a clean ppm water say 0-150ppm at most to start out with because the soil or nutrients you add will raise is substantially. The ph need to be between 5.5 - 7.5 if you want any good growth at all.

This is what my ppm pen says on the back:

How pure is your water?
TDS is parts per million (ppm)
0-50= Ideal drinking water, Reverse Osmosis, DI, Distillation etc.
50-100= Carbon filters, mt. springs, aquifers
100-200= Hard Water
200-400= Marginally Acceptable (Average Tap Water)
400-500= High TDS from tap or mineral water
500+ = U.S. EPA's max contaminant level (And mine was around 650 that was when i lived in Texas though)

Where i live now my ppm is 50-100.

I won't fuss with soil anymore now that i've learned how to grow hydroponically. Unless i get some cacti.

so do you mean water it with water spray once every 2-3 days? i usually give it 5-6 sprays just so the soil is damp. is that enough water for 2-3 days? concidering the air in house can get very dry??