Oh and the answer to your question is... probably toss up between shrooms or acid. I can be a little anxious but man, when I get into my shrooms/lsd vibe I am just the (genuinely) happiest person alive... cannot stop laughing hysterically and smiling.

Although I gotta vouch for my friend, once we were in a hotel with another guy and this hot Tibetan chick, smoking salvia, and when he took his hit he emitted this INSANELY AWESOME laugh that rose and rose and rose (and rose) in intensity, I swear it was like a diabolical clown/jester was projecting through him via some alternate dimension, and it had the effect of a self-feedback mechanism, that is making everyone in the room laugh SO hard which in turn made him laugh even harder and every second that it went on I couldn't believe it was STILL going and STILL getting louder .. we couldn't even speak because we were gasping for air I could only elbow him in the ribs almost uncontrollably because I couldn't speak and had tears in my eyes and that in turn made him laugh even harder.. when he stopped, everyone gave each other this sheepish look cause you could hear the damn thing ECHOING and reverbating through the halls of the hotel and at that point we were like "oh shi~t we might have just blown the spot up..."

Lmao.

LSD. I had one trip where about 5 of us were in a room, laughing pretty much constantly for 8 hrs... About half way through I started to think I was going mad, which made me laugh harder, and then it became extremely uncomfortable, my stomach muscles and face were in quite a lot of pain from all the laughing. I just had to laugh it off until the trip subsided

Cannabis, shrooms and acid are usually too overwhelming.

Easily lsd comes out on top for me. When you find yourself looking at the outside world through a slit in a blind and you see a guy drinking tea in his back garden and you think its the funniest situation known to man then you know its good drugs. Weed comes second followed by shrooms.

The funniest night ever was me and a friend on acid and a british comedian called charlie chuck came on the james whale radio show at 2 in the morning (its caled radio show but it's on the tv) He came on the stage and was smashing things and saying the most ridiculous things. The timing was perfect and we laughed in silence for about a good solid half hour. If you know what im talking about a silent laugh is when ypour gripped in a clench of hilarity and you cant even make a sound and your body gets all contorted until eventually you can get a breath. It's literally like dying laughing. It's the best feeling ever imo

Practically any drug when I was a young'un. From the time that weed started working on me (before 12 I couldn't get high from it)...'til like 16 or 17 anything remotely mind altering would induce fits of hysterical laughter at some point. (Shrooms, Acid, Ganj, Red Wine... whatever.)

Later, as the "seriousness" of the world began to set in, this foolish, pointless laughter subsided and was replaced by the periodic but more profound "eureka" laughter which descends on one when everything finally makes sense, and for that moment in time you actually get the cosmic joke.

I would have to say that my most uncontrollable laughter has come from new highs. 1st time I did Peyote I saw a gang fight and it made me laugh despite the fact that I knew it was serious shit and furthermore, that any noise we made might alert the combatants to our presence hiding behind some bushes.

1st salvia was a virtual laugh fest... though I tend not to like that drug, and haven't been a fan of it since my 80x experiments back in the 90's.

Of course there are plenty of exceptions... I didn't get my first Ayahuasca laugh-a-thon until perhaps the 3rd or 4th time. Nepenthé was a crack up the 3rd time as well.

Novel combinations can do it as well. N20 and anything tends to bring big smiles... if not actual laughter.

I suppose, the problem with uncontrollable laughter is the whole uncontrollable part. At this stage in my entheogenic career, I am rarely if ever truly out of control. Well beyond states that would have been irresponsibly out of control in my youth? Fo sheezie. But it is all rather familiar now. Hmmm... Perhaps I will consciously go for a gut laughter sesh on my next outing. Like Felix the Cat.

Heheheh

We had a bunch of friends in the House and we were smoking "100x SPACE spice" i think, and I was laughing so hard, that my wife and to drag me out of the living room to the bedroom.

The second time was when my wife was sleeping, I was smoking weed via easy vape. I was watching netflix's "the whites kids you know" and the epiosode were he, dose the John Williams impression, that had me laughing so hard. lol